Introduction Astrocytes are the most abundant cell type in the central nervous system (CNS).
They play a pivotal role in supporting neuronal function and maintaining homeostasis by …

Alzheimer's Disease (AD) pathology has been increasingly explored through single-cell and
single-nucleus RNA-sequencing (scRNA-seq & snRNA-seq) and spatial transcriptomics …

Loss-of-function mutations in the TLDc family of proteins cause a range of severe childhood-
onset neurological disorders with common clinical features that include cerebellar …

Alzheimer's Disease (AD) is a neurodegenerative malady predominantly affecting the
elderly and exhibits its debilitating effects on a dementia-prone population. Recently, the …

Alzheimer's disease (AD) and type 2 diabetes mellitus (T2DM) are two common diseases
that affect the elderly population worldwide. The identification of common genes associated …

Despite genome-wide association studies of late-onset Alzheimer's disease (LOAD) having
identified many genetic risk loci 1-6, the underlying disease mechanisms remain largely …

Recent advancements in the use of single-cell technologies in large cohort studies enable
the investigation of cellular response and mechanisms associated with disease outcome …

With the recent advancement in single-cell technologies and the increased availability of
integrative tools, challenges arise in easy and fast access to large collections of cell atlas …