Expanding chemistry through in vitro and in vivo biocatalysis

EN Kissman, MB Sosa, DC Millar, EJ Koleski… - Nature, 2024 - nature.com
Living systems contain a vast network of metabolic reactions, providing a wealth of enzymes
and cells as potential biocatalysts for chemical processes. The properties of protein and cell …

Multienzymatic Synthesis of γ‐Lactam Building Blocks from Unsaturated Esters and Hydroxylamine

C Jäger, M Nieger, K Rissanen… - European Journal of …, 2023 - Wiley Online Library
The assembly of enzymatic cascades and multi‐step reaction sequences represents an
attractive alternative to traditional synthetic‐organic approaches. The biocatalytic reaction …

Computational Modeling of the Enzymatic Achmatowicz Rearrangement by Heme-Dependent Chloroperoxidase: Reaction Mechanism, Enantiopreference …

F Chen, C Zhang, S Zhang, W Zhang… - Journal of Chemical …, 2025 - ACS Publications
The chloroperoxidase from Caldariomyces fumago (Cf CPO) catalyzes the oxidative ring
expansion of α-heterofunctionalized furans via the Achmatowicz rearrangement, providing …

Green method of synthesizing l-malate from d-glucose via CO 2 fixation using an ATP-free in vitro synthetic enzymatic biosystem

L Fan, S Sun, Z Zhang, Y Qin, PR Jensen, C You - Green Chemistry, 2024 - pubs.rsc.org
In conjunction with the pressing global issue of climate change and the associated concern
over global warming, increasing interest has emerged in the exploration of carbon dioxide …

Six-membered ring systems: With O and/or S atoms

CMM Santos, AMS Silva - Progress in Heterocyclic Chemistry, 2023 - Elsevier
This chapter covers the most recent advances on the synthesis of O-and S-6-membered
heterocycles reported during 2022. This personal overview is focused on the new …