New pieces for an old puzzle: Approaching Parkinson's disease from translatable animal models, gut microbiota modulation, and lipidomics

L Ortega Moreno, A Bagues, V Martínez, R Abalo - Nutrients, 2023 - mdpi.com
Parkinson's disease (PD) is a severe neurodegenerative disease characterized by disabling
motor alterations that are diagnosed at a relatively late stage in its development, and non …

[HTML][HTML] Kaempferol counteracts toxicity induced by 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine in D. melanogaster: An implication of its mitoprotective activity

AO Adedara, G Wildner, JS Loreto, MM Dos Santos… - Neurotoxicology, 2023 - Elsevier
The current study aimed to investigate whether kaempferol (KMP), the major bioactive
component of green leafy vegetables, could counteract the toxicity elicited by 1-methyl-4 …

No Evidence of Sensory Neuropathy in a Traditional Mouse Model of Idiopathic Parkinson's Disease

M Faisal, A Rusetskaya, L Väli, P Taba, A Minajeva… - Cells, 2024 - mdpi.com
Parkinson's disease (PD) is the second-most common neurodegenerative disorder
worldwide and is diagnosed based on motor impairments. Non-motor symptoms are also …

Saponin‐Encapsulated Microbubbles Protect Dopaminergic Neurons from MPTP‐Induced Oxidative Stress Injury

Z Zhang, B Xu, T Lv, Y Shi, M Wang, D Hu… - Advanced …, 2023 - Wiley Online Library
Parkinson's disease (PD) is starting at younger ages. In order to reduce the risk of PD in
young people, Rb3 is selected as an active ingredient and assembled into Rb3 …

Quantification of Non-Motor Symptoms in Parkinsonian Cynomolgus Monkeys

Y Bao, C Gan, Z Chen, Z Qi, Z Meng, F Yue - Brain Sciences, 2023 - mdpi.com
Background: Parkinson's disease (PD) is a neurodegenerative disorder that features motor
and non-motor deficits. The use of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) …