Although drug development has advanced for autoimmune diseases, many current
therapies are hampered by adverse effects and the frequent destruction or inactivation of …

The development of insulin-producing pancreatic beta (β)-cells represents the culmination of
a complex developmental program. Cells of the posterior foregut assume a pancreatic …

The mechanisms that regulate pancreatic β cell mass are poorly understood. While
autoimmune and pharmacological destruction of insulin-producing β cells is often …

Several recent studies have suggested that the adult bone marrow harbors cells that can
influence β-cell regeneration in diabetic animals. Other reports, however, have contradicted …

The role of Th17 cells in type I diabetes (TID) remains largely unknown. Glutamic acid
decarboxylase (GAD) sequence 206–220 (designated GAD2) represents a late-stage …

Aims/hypothesis We investigated whether there was evidence of attempted beta cell
regeneration in the pancreas obtained from a patient with recent-onset type 1 diabetes, and …

Diabetes is associated with a paucity of insulin-producing β-cells. With the goal of finding
therapeutic routes to treat diabetes, we aim to find molecular and cellular mechanisms …

Limitations in islet β-cell transplantation as a therapeutic option for type 1 diabetes have
prompted renewed interest in islet regeneration as a source of new islets. In this study we …

Type I diabetes mellitus is caused by autoimmune destruction of pancreatic β cells, and
effective treatment of the disease might require rescuing β cell function in a context of …

Patients with diabetes experience decreased insulin secretion that is linked to a significant
reduction in the number of islet cells. Reversal of diabetes can be achieved through islet …