Novel tau biomarkers phosphorylated at T181, T217 or T231 rise in the initial stages of the preclinical Alzheimer's continuum when only subtle changes in Aβ …
In Alzheimer's disease (AD), tau phosphorylation in the brain and its subsequent release
into cerebrospinal fluid (CSF) and blood is a dynamic process that changes during disease …
into cerebrospinal fluid (CSF) and blood is a dynamic process that changes during disease …
Neurogranin and VILIP-1 as molecular indicators of neurodegeneration in Alzheimer's disease: A systematic review and meta-analysis
M Dulewicz, A Kulczyńska-Przybik… - International journal of …, 2020 - mdpi.com
Neurogranin (Ng) and visinin-like protein 1 (VILIP-1) are promising candidates for
Alzheimer's Disease (AD) biomarkers closely related to synaptic and neuronal …
Alzheimer's Disease (AD) biomarkers closely related to synaptic and neuronal …
Tau and MAPT genetics in tauopathies and synucleinopathies
MAPT encodes the microtubule-associated protein tau, which is the main component of
neurofibrillary tangles (NFTs) and found in other protein aggregates. These aggregates are …
neurofibrillary tangles (NFTs) and found in other protein aggregates. These aggregates are …
Role of microglial cells in Alzheimer's disease tau propagation
Uncontrolled immune response in the brain contributes to the progression of all
neurodegenerative disease, including Alzheimer's disease (AD). Recent investigations have …
neurodegenerative disease, including Alzheimer's disease (AD). Recent investigations have …
IL-1β, IL-6, IL-10, and TNF α single nucleotide polymorphisms in human influence the susceptibility to Alzheimer's disease pathology
M Babić Leko, M Nikolac Perković… - Journal of …, 2020 - content.iospress.com
Background: Neuroinflammation plays an important role in Alzheimer's disease (AD). During
this process, activated microglia release pro-inflammatory cytokines such as interleukin (IL) …
this process, activated microglia release pro-inflammatory cytokines such as interleukin (IL) …
The MAPT H1 Haplotype Is a Risk Factor for Alzheimer's Disease in APOE ε4 Non-carriers
An ancestral inversion of 900 kb on chromosome 17q21, which includes the microtubule-
associated protein tau (MAPT) gene, defines two haplotype clades in Caucasians (H1 and …
associated protein tau (MAPT) gene, defines two haplotype clades in Caucasians (H1 and …
Total tau in cerebrospinal fluid detects treatment responders among spinal muscular atrophy types 1–3 patients treated with nusinersen
Aims Considering the substantial variability in treatment response across patients with
spinal muscular atrophy (SMA), reliable markers for monitoring response to therapy and …
spinal muscular atrophy (SMA), reliable markers for monitoring response to therapy and …
A meta-analysis on the levels of VILIP-1 in the CSF of Alzheimer's disease compared to normal controls and other neurodegenerative conditions
IA Mavroudis, F Petridis, S Chatzikonstantinou… - Aging Clinical and …, 2021 - Springer
Alzheimer's disease (AD) is a progressing neurodegenerative disorder and the main cause
of serious irreversible cognitive decline in elderly people. Visinin-like protein 1 (VILIP-1) is a …
of serious irreversible cognitive decline in elderly people. Visinin-like protein 1 (VILIP-1) is a …
The role of frontotemporal dementia associated genes in patients with Alzheimer's disease
X Xiao, Z Yuan, L Guo, X Liao, Y Zhou, W Zhang… - Neurobiology of …, 2021 - Elsevier
Alzheimer's disease (AD) and frontotemporal dementia (FTD) overlap clinically and
pathologically. However, the role of FTD-associated genes in patients with AD remained …
pathologically. However, the role of FTD-associated genes in patients with AD remained …
Variants in PPP2R2B and IGF2BP3 are associated with higher tau deposition
VK Ramanan, X Wang, SA Przybelski… - Brain …, 2020 - academic.oup.com
Tau deposition is a key biological feature of Alzheimer's disease that is closely related to
cognitive impairment. However, it remains poorly understood why certain individuals may be …
cognitive impairment. However, it remains poorly understood why certain individuals may be …