Oxidative cyclization in natural product biosynthesis
MC Tang, Y Zou, K Watanabe, CT Walsh… - Chemical …, 2017 - ACS Publications
Oxidative cyclizations are important transformations that occur widely during natural product
biosynthesis. The transformations from acyclic precursors to cyclized products can afford …
biosynthesis. The transformations from acyclic precursors to cyclized products can afford …
Dioxygen activation by nonheme iron enzymes with the 2-His-1-carboxylate facial triad that generate high-valent oxoiron oxidants
S Kal, L Que - JBIC Journal of Biological Inorganic Chemistry, 2017 - Springer
Abstract The 2-His-1-carboxylate facial triad is a widely used scaffold to bind the iron center
in mononuclear nonheme iron enzymes for activating dioxygen in a variety of oxidative …
in mononuclear nonheme iron enzymes for activating dioxygen in a variety of oxidative …
Amazing diversity in biochemical roles of Fe (II)/2-oxoglutarate oxygenases
CQ Herr, RP Hausinger - Trends in Biochemical Sciences, 2018 - cell.com
Since their discovery in the 1960s, the family of Fe (II)/2-oxoglutarate-dependent
oxygenases has undergone a tremendous expansion to include enzymes catalyzing a vast …
oxygenases has undergone a tremendous expansion to include enzymes catalyzing a vast …
Homogeneous oxygenase catalysis
Y Liang, J Wei, X Qiu, N Jiao - Chemical reviews, 2018 - ACS Publications
Oxygenases-catalyzed reductive activation of molecular oxygen and incorporation of O
atoms into an organic molecule is undoubtedly one of the most attractive research areas …
atoms into an organic molecule is undoubtedly one of the most attractive research areas …
Recent examples of α-ketoglutarate-dependent mononuclear non-haem iron enzymes in natural product biosyntheses
Covering: up to 2018 α-Ketoglutarate (αKG, also known as 2-oxoglutarate)-dependent
mononuclear non-haem iron (αKG-NHFe) enzymes catalyze a wide range of biochemical …
mononuclear non-haem iron (αKG-NHFe) enzymes catalyze a wide range of biochemical …
Second‐coordination sphere effects on selectivity and specificity of heme and nonheme iron enzymes
SP de Visser - Chemistry–A European Journal, 2020 - Wiley Online Library
Mononuclear iron‐containing enzymes are highly versatile oxidants that often react
stereospecifically and/or regioselectively with substrates. Combined experimental and …
stereospecifically and/or regioselectively with substrates. Combined experimental and …
Mechanistic studies of aziridine formation catalyzed by mononuclear non-heme iron enzymes
Aziridines are compounds with a nitrogen-containing three-membered ring. When it is
incorporated into natural products, the reactivity of the strained ring often drives the …
incorporated into natural products, the reactivity of the strained ring often drives the …
A computational study of the Fenton reaction in different pH ranges
HF Lu, HF Chen, CL Kao, I Chao… - Physical Chemistry …, 2018 - pubs.rsc.org
The reaction of iron (II) and hydrogen peroxide, namely the Fenton reaction, is well-known
for its strong oxidizing capability. While the Fenton reactions are ubiquitous and have wide …
for its strong oxidizing capability. While the Fenton reactions are ubiquitous and have wide …
Catalysis by the non-heme iron (II) histone demethylase PHF8 involves iron center rearrangement and conformational modulation of substrate orientation
PHF8 (KDM7B) is a human non-heme 2-oxoglutarate (2OG) JmjC domain oxygenase that
catalyzes the demethylation of the di/mono-Nε-methylated K9 residue of histone H3. Altered …
catalyzes the demethylation of the di/mono-Nε-methylated K9 residue of histone H3. Altered …
Epoxidation catalyzed by the nonheme iron (II)-and 2-oxoglutarate-dependent oxygenase, AsqJ: Mechanistic elucidation of oxygen atom transfer by a ferryl …
Mechanisms of enzymatic epoxidation via oxygen atom transfer (OAT) to an olefin moiety is
mainly derived from the studies on thiolate-heme containing epoxidases, such as …
mainly derived from the studies on thiolate-heme containing epoxidases, such as …