Dysregulation of mRNA translation is a frequent feature of neoplasia. Many oncogenes and tumour suppressors affect the translation machinery, making aberrant translation a …
M Yang, Y Lu, W Piao, H Jin - Biomolecules, 2022 - mdpi.com
The mechanistic/mammalian target of rapamycin (mTOR) plays a master role in cell proliferation and growth in response to insulin, amino acids, energy levels, and oxygen …
J Pelletier, N Sonenberg - Annual review of biochemistry, 2019 - annualreviews.org
The stage at which ribosomes are recruited to messenger RNAs (mRNAs) is an elaborate and highly regulated phase of protein synthesis. Upon completion of this step, a ribosome is …
The mechanisms that link environmental and intracellular stimuli to mitochondrial functions, including fission/fusion, ATP production, metabolite biogenesis, and apoptosis, are not well …
PP Roux, I Topisirovic - Molecular and cellular biology, 2018 - Am Soc Microbiol
Translation is a key step in the regulation of gene expression and one of the most energy- consuming processes in the cell. In response to various stimuli, multiple signaling pathways …
Protein synthesis is one of the most energy consuming processes in the cell. The mammalian/mechanistic target of rapamycin (mTOR) is a serine/threonine kinase that …
M Morita, SP Gravel, V Chenard, K Sikström, L Zheng… - Cell metabolism, 2013 - cell.com
Summary mRNA translation is thought to be the most energy-consuming process in the cell. Translation and energy metabolism are dysregulated in a variety of diseases including …
Eukaryotic mRNAs contain a 5′ cap structure that is crucial for recruitment of the translation machinery and initiation of protein synthesis. mRNA recognition is thought to require direct …
The protein kinase mechanistic target of rapamycin (mTOR) functions as a central regulator of metabolism, integrating diverse nutritional and hormonal cues to control anabolic …