The pathology and pathophysiology of vascular dementia

RN Kalaria - Neuropharmacology, 2018 - Elsevier
Vascular dementia (VaD) is widely recognised as the second most common type of
dementia. Consensus and accurate diagnosis of clinically suspected VaD relies on wide …

Neuropathological diagnosis of vascular cognitive impairment and vascular dementia with implications for Alzheimer's disease

RN Kalaria - Acta neuropathologica, 2016 - Springer
Vascular dementia (VaD) is recognised as a neurocognitive disorder, which is explained by
numerous vascular causes in the general absence of other pathologies. The heterogeneity …

Diagnostic criteria for vascular cognitive disorders: a VASCOG statement

P Sachdev, R Kalaria, J O'Brien, I Skoog… - Alzheimer Disease & …, 2014 - journals.lww.com
Background: Several sets of diagnostic criteria have been published for vascular dementia
since the 1960s. The continuing ambiguity in vascular dementia definition warrants a critical …

Association of cerebral microbleeds with cognitive decline and dementia

S Akoudad, FJ Wolters, A Viswanathan… - JAMA …, 2016 - jamanetwork.com
Importance Cerebral microbleeds are hypothesized downstream markers of brain damage
caused by vascular and amyloid pathologic mechanisms. To date, whether their presence is …

Intracerebral haemorrhage: mechanisms of injury and therapeutic targets

RF Keep, Y Hua, G Xi - The Lancet Neurology, 2012 - thelancet.com
Intracerebral haemorrhage accounts for about 10–15% of all strokes and is associated with
high mortality and morbidity. No successful phase 3 clinical trials for this disorder have been …

Sporadic cerebral amyloid angiopathy revisited: recent insights into pathophysiology and clinical spectrum

A Charidimou, Q Gang, DJ Werring - Journal of Neurology …, 2012 - jnnp.bmj.com
Sporadic cerebral amyloid angiopathy (CAA) is a common age related cerebral small vessel
disease, characterised by progressive deposition of amyloid-β (Aβ) in the wall of small to …

Cerebral microbleeds are associated with worse cognitive function: the Rotterdam Scan Study

MMF Poels, MA Ikram, A van der Lugt, A Hofman… - Neurology, 2012 - AAN Enterprises
Objective: Cerebral microbleeds are frequently found in the general elderly population and
may reflect underlying vascular disease, but their role in cognitive function is unknown …

Structural imaging measures of brain aging

SN Lockhart, C DeCarli - Neuropsychology review, 2014 - Springer
During the course of normal aging, biological changes occur in the brain that are associated
with changes in cognitive ability. This review presents data from neuroimaging studies of …

The impact of cerebrovascular aging on vascular cognitive impairment and dementia

T Yang, Y Sun, Z Lu, RK Leak, F Zhang - Ageing research reviews, 2017 - Elsevier
As human life expectancy rises, the aged population will increase. Aging is accompanied by
changes in tissue structure, often resulting in functional decline. For example, aging within …

Cerebral microbleeds: a review of clinical, genetic, and neuroimaging associations

PA Yates, VL Villemagne, KA Ellis… - Frontiers in …, 2014 - frontiersin.org
Cerebral microbleeds (microbleeds) are small, punctuate hypointense lesions seen in T2*
Gradient-Recall Echo (GRE) and Susceptibility-Weighted (SWI) Magnetic Resonance …