[HTML][HTML] Science and technology roadmap for graphene, related two-dimensional crystals, and hybrid systems

AC Ferrari, F Bonaccorso, V Fal'Ko, KS Novoselov… - Nanoscale, 2015 - pubs.rsc.org
We present the science and technology roadmap for graphene, related two-dimensional
crystals, and hybrid systems, targeting an evolution in technology, that might lead to impacts …

Microfluidic modelling of the tumor microenvironment for anti-cancer drug development

M Shang, RH Soon, CT Lim, BL Khoo, J Han - Lab on a Chip, 2019 - pubs.rsc.org
Cancer is the leading cause of death worldwide. The complex and disorganized tumor
microenvironment makes it very difficult to treat this disease. The most common in vitro drug …

Immortalizing cells for human consumption

E Soice, J Johnston - International Journal of Molecular Sciences, 2021 - mdpi.com
The need to produce immortal, food-relevant cell lines is one of the most pressing
challenges of cellular agriculture, the field which seeks to produce meat and other animal …

Patient-derived induced pluripotent stem cells in cancer research and precision oncology

EP Papapetrou - Nature medicine, 2016 - nature.com
Together with recent advances in the processing and culture of human tissue,
bioengineering, xenotransplantation and genome editing, Induced pluripotent stem cells …

Glucocerebrosidase mutations in Parkinson disease

G O'Regan, RM deSouza, R Balestrino… - Journal of …, 2017 - content.iospress.com
Following the discovery of a higher than expected incidence of Parkinson Disease (PD) in
Gaucher disease, a lysosomal storage disorder, mutations in the glucocerebrocidase (GBA) …

Mesenchymal stem cells in suppression or progression of hematologic malignancy: current status and challenges

MW Lee, S Ryu, DS Kim, JW Lee, KW Sung, HH Koo… - Leukemia, 2019 - nature.com
Mesenchymal stem cells (MSCs) are known for being multi-potent. However, they also
possess anticancer properties, which has prompted efforts to adapt MSCs for anticancer …

Cross-talks among GBA mutations, glucocerebrosidase, and α-synuclein in GBA-associated Parkinson's disease and their targeted therapeutic approaches: a …

T Behl, G Kaur, O Fratila, C Buhas… - Translational …, 2021 - Springer
Current therapies for Parkinson's disease (PD) are palliative, of which the
levodopa/carbidopa therapy remains the primary choice but is unable to modulate the …

Drug screening for human genetic diseases using iPSC models

MS Elitt, L Barbar, PJ Tesar - Human molecular genetics, 2018 - academic.oup.com
Induced pluripotent stem cells (iPSCs) enable the generation of previously unattainable,
scalable quantities of disease-relevant tissues from patients suffering from essentially any …

Management and potentialities of primary cancer cultures in preclinical and translational studies

G Miserocchi, L Mercatali, C Liverani, A De Vita… - Journal of translational …, 2017 - Springer
The use of patient-derived primary cell cultures in cancer preclinical assays has increased in
recent years. The management of resected tumor tissue remains complex and a number of …

Cellular mechanisms of FGF-stimulated tissue repair

I Prudovsky - Cells, 2021 - mdpi.com
Growth factors belonging to the FGF family play important roles in tissue and organ repair
after trauma. In this review, I discuss the regulation by FGFs of the aspects of cellular …