DNA topoisomerases constitute a large family of enzymes that are essential for all domains
of life. Although they share general reaction chemistry and the capacity to govern DNA …

Cancer, characterized by uncontrolled malignant neoplasm, is a leading cause of death in
both advanced and emerging countries. Although, ample drugs are accessible in the market …

DNA topoisomerases are important cellular enzymes found in almost all types of living cells
(eukaryotic and prokaryotic). These enzymes are essential for various DNA metabolic …

Evodiamine (Evo) is a quinazolinocarboline alkaloid found in Evodia rutaecarpa and
exhibits moderate antiproliferative activity. Herein, we report using a scaffold-hopping …

Phytoalexins are substances produced by plants that act as potent inhibitors of pathogens.
Pterocarpans are biologically active isoflavonoids most commonly found in the family …

The search for new, effective, and low-toxic anticancer agents is one of the most important
tasks of modern medicinal chemistry. In general, the solution to this problem comes down to …

DNA topoisomerase II (TOP2) is a wellknown anticancer target. Its inhibitors are among the
most effective anticancer drugs currently in clinical use. TOP2-targeting agents fall into two …

Cell cycle control genes are frequently mutated in cancer cells, which usually display higher
rates of proliferation than normal cells. Dysregulated mitosis leads to genomic instability …

The ability of oxindolimine copper (ii) and zinc (ii) complexes, known to have antitumor
activity, to inhibit human topoisomerase IB has been tested through enzymatic kinetic assays …

DNA topoisomerase I enzymes relieve the torsional strain in DNA; they are essential for
fundamental molecular processes such as DNA replication, transcription, recombination …