Abstract The TFOS DEWS II Pathophysiology Subcommittee reviewed the mechanisms
involved in the initiation and perpetuation of dry eye disease. Its central mechanism is …

Hyaluronan (HA) is a high molecular weight glycosaminoglycan of the extracellular matrix
(ECM), which is particularly abundant in soft connective tissues. Solutions of HA can be …

Successful regeneration of cartilage tissue at a clinical scale has been a tremendous
challenge in the past decades. Microcarriers (MCs), usually used for cell and drug delivery …

When lubricated by synovial fluid, articular cartilage provides some of the lowest friction
coefficients found in nature. While it is known that macromolecular constituents of synovial …

Partial joint repair is a surgical procedure where an artificial material is used to replace
localised chondral damage. These artificial bearing surfaces must articulate against …

In this review, we discuss the concept of bioinspired lubrication using novel polymeric
structures, which has led to producing a myriad of new systems with effective and …

Hydrogels consist of a cross-linked polymer matrix imbibed with a solvent such as water at
volume fractions that can exceed 90%. They are important in many scientific and …

Polyacrylamide (PAAm) hydrogels are excellent synthetic materials for in vitro biotribology
studies. Recent work with hydrogels sliding in a Gemini contact has revealed unique friction …

The mechanical forces between the lid wiper and the ocular surface, and between a contact
lens and the lid wiper, are reported to be related to dry eye symptoms. Furthermore, the …

Hydrogels are often used as model systems for articular cartilage due to similarities in their
tribological properties. However, neither the structures nor the friction mechanisms of either …