In-vivo and ex-vivo optical clearing methods for biological tissues

I Costantini, R Cicchi, L Silvestri, F Vanzi… - Biomedical optics …, 2019 - opg.optica.org
Every optical imaging technique is limited in its penetration depth by scattering occurring in
biological tissues. Possible solutions to overcome this problem consist of limiting the …

Ultradeep photothermal therapy strategies

Y Chu, XQ Xu, Y Wang - The Journal of Physical Chemistry Letters, 2022 - ACS Publications
Photothermal therapy (PTT) mediated by the second near-infrared light (NIR-II) is
considered as the most promising PTT in deep tissues due to the superior penetrability of …

Recent progress in tissue optical clearing for spectroscopic application

AY Sdobnov, ME Darvin, EA Genina… - … Acta Part A: Molecular …, 2018 - Elsevier
This paper aims to review recent progress in optical clearing of the skin and over naturally
turbid biological tissues and blood using this technique in vivo and in vitro with multiphoton …

Biomedical applications of tissue clearing and three-dimensional imaging in health and disease

MV Gomez-Gaviro, D Sanderson, J Ripoll, M Desco - Iscience, 2020 - cell.com
Summary Three-dimensional (3D) optical imaging techniques can expand our knowledge
about physiological and pathological processes that cannot be fully understood with 2D …

Second near-infrared photothermal therapy with superior penetrability through skin tissues

Y Chu, S Liao, H Liao, Y Lu, X Geng, D Wu… - CCS …, 2022 - chinesechemsoc.org
Photothermal therapy (PTT) triggered by second near-infrared (NIR-II) light (1000–1400 nm)
has shown great potential in tumor ablation because of its good tissue penetrability …

Long-term in vivo imaging of mouse spinal cord through an optically cleared intervertebral window

W Wu, S He, J Wu, C Chen, X Li, K Liu, JY Qu - Nature communications, 2022 - nature.com
The spinal cord accounts for the main communication pathway between the brain and the
peripheral nervous system. Spinal cord injury is a devastating and largely irreversible …

Hydrogen bound water profiles in the skin influenced by optical clearing molecular agents—Quantitative analysis using confocal Raman microscopy

AY Sdobnov, ME Darvin, J Schleusener… - Journal of …, 2019 - Wiley Online Library
Confocal Raman microscopy has been used to measure depth‐dependent profiles of
porcine skin ex vivo in the high wavenumber region after application of molecular optical …

Photoacoustic imaging of brain functions: wide filed‐of‐view functional imaging with high spatiotemporal resolution

T Jin, W Qi, X Liang, H Guo, Q Liu… - Laser & Photonics …, 2022 - Wiley Online Library
Neuroimaging techniques can reveal complex brain functions associated with behaviors
and emotions. However, most existing neuroimaging methods suffer from balancing …

Skin optical clearing enabled by dissolving hyaluronic acid microneedle patches

M Ouyang, X Wang, Y Fu, G Xie, S Du, Y Li… - International Journal of …, 2022 - Elsevier
Optical imaging and phototherapy are of great significance in the detection, diagnosis, and
therapy of diseases. Depth of light in the skin tissues in optical imaging and phototherapy …

Delivery and kinetics of immersion optical clearing agents in tissues: Optical imaging from ex vivo to in vivo

T Yu, X Zhong, D Li, J Zhu, VV Tuchin, D Zhu - Advanced Drug Delivery …, 2024 - Elsevier
Advanced optical imaging provides a powerful tool for the structural and functional analysis
of tissues with high resolution and contrast, but the imaging performance decreases as light …