Although the development of mitochondrial therapies has largely focused on diseases
caused by mutations in mitochondrial DNA or in nuclear genes encoding mitochondrial …

Mitochondria are recognized as one of the most important targets for new drug design in
cancer, cardiovascular, and neurological diseases. Currently, the most effective way to …

In recent years, fluorescent dyes have been frequently used for monitoring mitochondrial
membrane potential to evaluate mitochondrial viability and function. However, the …

Mitochondria are essential regulators of cellular energy and metabolism, and have a crucial
role in sustaining the growth and survival of cancer cells. A central function of mitochondria …

Abstract Purpose of Review Mitochondria play various roles that are important for cell
function and survival; therefore, significant mitochondrial dysfunction may have chronic …

Mitochondria play an important role in maintaining cardiac homeostasis by supplying the
major energy required for cardiac excitation–contraction coupling as well as controlling the …

The development of transition metal catalysts capable of promoting non-natural
transformations within living cells can open significant new avenues in chemical and cell …

Neurodegenerative diseases are a spectrum of chronic, debilitating disorders characterised
by the progressive degeneration and death of neurons. Mitochondrial dysfunction has been …

Mitochondrial oxidative damage has long been known to contribute to damage in conditions
such as ischaemia–reperfusion (IR) injury in heart attack. Over the past years, we have …

Oxidative stress is a major component of most major retinal diseases. Many extrinsic anti-
oxidative strategies have been insufficient at counteracting one of the predominant intrinsic …