Self-assembled monolayers (SAMs) represent highly ordered molecular materials with
versatile biochemical features and multidisciplinary applications. Research on SAMs has …

CRISPR technology has transformed multiple fields, including cancer and immunology.
CRISPR‐based gene editing and screening empowers direct genomic manipulation of …

Cell-type-specific in vivo delivery of genome editing molecules is the next breakthrough that
will drive biological discovery and transform the field of cell and gene therapy. Here, we …

The delivery of CRISPR ribonucleoproteins (RNPs) for genome editing in vitro and in vivo
has important advantages over other delivery methods, including reduced off-target and …

The therapeutic potential of the CRISPR-Cas9 gene editing system in treating numerous
genetic disorders is immense. To fully realize this potential, it is crucial to achieve safe and …

Organoids, combined with genetic editing strategies, have the potential to offer rapid and
efficient investigation of gene function in many models of human disease. However, to date …

As a vital project of forward chemical genetic research, target deconvolution aims to identify
the molecular targets of an active hit compound. Chemoproteomics, either with chemical …

Protein biologics are powerful therapeutic agents with diverse inhibitory and enzymatic
functions. However, their clinical use has been limited to extracellular applications due to …

Nucleic acid drugs have great potential in treating various diseases due to their advantage
of directly acting on disease-causing genes. However, since they need to overcome multiple …

Advancements in gene delivery and editing have expanded the applications of autologous
hematopoietic stem and progenitor cells (HSPCs) for the treatment of monogenic and …