The NLRP3 inflammasome in non-alcoholic fatty liver disease and steatohepatitis: Therapeutic targets and treatment

L Yu, W Hong, S Lu, Y Li, Y Guan, X Weng… - Frontiers in …, 2022 - frontiersin.org
Non-alcoholic fatty liver disease (NAFLD) is among the most prevalent primary liver
diseases worldwide and can develop into various conditions, ranging from simple steatosis …

[HTML][HTML] Luteolin as a potential hepatoprotective drug: Molecular mechanisms and treatment strategies

C Yao, S Dai, C Wang, K Fu, R Wu, X Zhao… - Biomedicine & …, 2023 - Elsevier
Luteolin is a flavonoid widely present in various traditional Chinese medicines. In recent
years, luteolin has received more attention due to its impressive liver protective effect, such …

Exercise-induced irisin decreases inflammation and improves NAFLD by competitive binding with MD2

W Zhu, NE Sahar, HMA Javaid, ES Pak, G Liang… - Cells, 2021 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is a global clinical problem. The MD2-TLR4
pathway exacerbates NAFLD progression by promoting inflammation. Long-term exercise is …

Therapeutical properties of apigenin: A review on the experimental evidence and basic mechanisms

Z Mushtaq, NB Sadeer, M Hussain… - … Journal of Food …, 2023 - Taylor & Francis
ABSTRACT Apigenin (4,'5, 7-trihydroxyflavone) is one of the most studied flavonoids with
low toxicity and abundantly present phenolic compound in the plant kingdom. The main …

Apigenin alleviates obesity-associated metabolic syndrome by regulating the composition of the gut microbiome

Y Qiao, Z Zhang, Y Zhai, X Yan, W Zhou, H Liu… - Frontiers in …, 2022 - frontiersin.org
The gut microbiota, often viewed as a “digestive organ,” can influence the development of
obesity and related metabolic disorders. Diet is significantly important in shaping the …

Beneficial impacts of fermented celery (Apium graveolens L.) juice on obesity prevention and gut microbiota modulation in high-fat diet fed mice

D Zhao, J Cao, H Jin, Y Shan, J Fang, F Liu - Food & Function, 2021 - pubs.rsc.org
Metabolic syndrome caused obesity has long been recognized as a risk of health. Celery
and celery extracts have various medicinal properties, such as anti-diabetes and anti …

Apigenin ameliorates hyperuricemic nephropathy by inhibiting URAT1 and GLUT9 and relieving renal fibrosis via the Wnt/β-catenin pathway

Y Li, Z Zhao, J Luo, Y Jiang, L Li, Y Chen, L Zhang… - Phytomedicine, 2021 - Elsevier
Background Hyperuricemia (HUA) is characterized by abnormal serum uric acid (UA) levels
and demonstrated to be involved in renal injury leading to hyperuricemic nephropathy (HN) …

Natural flavonoids: Potential therapeutic strategies for non-alcoholic fatty liver disease

P Tan, L Jin, X Qin, B He - Frontiers in Pharmacology, 2022 - frontiersin.org
The incidence of non-alcoholic fatty liver disease (NAFLD) is increasing rapidly worldwide;
however, there are currently limited treatments for NAFLD. The disease spectrum includes …

Apigenin alleviated high-fat-diet-induced hepatic pyroptosis by mitophagy-ROS-CTSB-NLRP3 pathway in mice and AML12 cells

Z Meng, M Gao, C Wang, S Guan… - Journal of Agricultural …, 2023 - ACS Publications
Apigenin is considered the most-known natural flavonoid and is abundant in a wide variety
of fruits and vegetables. A high fat diet (HFD) can induce liver injury and hepatocyte death in …

Chitosan oligosaccharide attenuates nonalcoholic fatty liver disease induced by high fat diet through reducing lipid accumulation, inflammation and oxidative stress in …

W Tao, W Sun, L Liu, G Wang, Z Xiao, X Pei, M Wang - Marine drugs, 2019 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) has become the most common chronic liver
disease closely associated with metabolic syndrome, but there are no validated …