Neurodegenerative diseases pose a substantial socioeconomic burden on society.
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …

Importance Parkinson disease is the second most common neurodegenerative disease
worldwide. Although no available therapies alter the underlying neurodegenerative process …

Parkinson’s Disease and Its Management - PMC Back to Top Skip to main content NIH NLM
Logo Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation Search …

Dopamine metabolism, alpha-synuclein pathology, and iron homeostasis have all been
implicated as potential contributors to the unique vulnerability of substantia nigra …

Involuntary movements, or dyskinesia, represent a debilitating complication of levodopa (L-
dopa) therapy for Parkinson's disease (PD). L-dopa-induced dyskinesia (LID) are ultimately …

Methods We used Canadian and American national guidelines to inform this review, in
addition to published systematic reviews that were known to us. We identified additional …

The objective was to update previous evidence‐based medicine reviews of treatments for
motor symptoms of Parkinson's disease published between 2002 and 2005. Level I …

Objective To summarize the 2010 EFNS/MDS‐ES evidence‐based treatment
recommendations for the management of P arkinson's disease (PD). This summary includes …

Parkinson's disease is a neurodegenerative process characterized by numerous motor and
nonmotor clinical manifestations for which effective, mechanism-based treatments remain …

The first years of Parkinson disease (PD) treatment are marked by good and sustained
responses to dopaminergic therapy. With disease progression and longer exposure to …