Roles of eukaryotic topoisomerases in transcription, replication and genomic stability
Topoisomerases introduce transient DNA breaks to relax supercoiled DNA, remove
catenanes and enable chromosome segregation. Human cells encode six topoisomerases …
catenanes and enable chromosome segregation. Human cells encode six topoisomerases …
Causes and consequences of replication stress
MK Zeman, KA Cimprich - Nature cell biology, 2014 - nature.com
Replication stress is a complex phenomenon that has serious implications for genome
stability, cell survival and human disease. Generation of aberrant replication fork structures …
stability, cell survival and human disease. Generation of aberrant replication fork structures …
Chromosome Duplication in Saccharomyces cerevisiae
SP Bell, K Labib - Genetics, 2016 - academic.oup.com
The accurate and complete replication of genomic DNA is essential for all life. In eukaryotic
cells, the assembly of the multi-enzyme replisomes that perform replication is divided into …
cells, the assembly of the multi-enzyme replisomes that perform replication is divided into …
Eukaryotic mismatch repair in relation to DNA replication
TA Kunkel, DA Erie - Annual review of genetics, 2015 - annualreviews.org
Three processes act in series to accurately replicate the eukaryotic nuclear genome. The
major replicative DNA polymerases strongly prevent mismatch formation, occasional …
major replicative DNA polymerases strongly prevent mismatch formation, occasional …
The impact of replication stress on replication dynamics and DNA damage in vertebrate cells
H Técher, S Koundrioukoff, A Nicolas… - Nature Reviews …, 2017 - nature.com
The interplay between replication stress and the S phase checkpoint is a key determinant of
genome maintenance, and has a major impact on human diseases, notably, tumour …
genome maintenance, and has a major impact on human diseases, notably, tumour …
Collisions between replication and transcription complexes cause common fragile site instability at the longest human genes
A Helmrich, M Ballarino, L Tora - Molecular cell, 2011 - cell.com
We show that the time required to transcribe human genes larger than 800 kb spans more
than one complete cell cycle, while their transcription speed equals that of smaller genes …
than one complete cell cycle, while their transcription speed equals that of smaller genes …
[HTML][HTML] Enzymatic removal of ribonucleotides from DNA is essential for mammalian genome integrity and development
The presence of ribonucleotides in genomic DNA is undesirable given their increased
susceptibility to hydrolysis. Ribonuclease (RNase) H enzymes that recognize and process …
susceptibility to hydrolysis. Ribonuclease (RNase) H enzymes that recognize and process …
Eukaryotic DNA replication fork
PMJ Burgers, TA Kunkel - Annual review of biochemistry, 2017 - annualreviews.org
This review focuses on the biogenesis and composition of the eukaryotic DNA replication
fork, with an emphasis on the enzymes that synthesize DNA and repair discontinuities on the …
fork, with an emphasis on the enzymes that synthesize DNA and repair discontinuities on the …
RNase H1 and H2 are differentially regulated to process RNA-DNA hybrids
A Lockhart, VB Pires, F Bento, V Kellner, S Luke-Glaser… - Cell reports, 2019 - cell.com
RNA-DNA hybrids are tightly regulated to ensure genome integrity. The RNase H enzymes
RNase H1 and H2 contribute to chromosomal stability through the removal of RNA-DNA …
RNase H1 and H2 contribute to chromosomal stability through the removal of RNA-DNA …
[HTML][HTML] RNase H2-initiated ribonucleotide excision repair
JL Sparks, H Chon, SM Cerritelli, TA Kunkel… - Molecular cell, 2012 - cell.com
Ribonucleotides are incorporated into DNA by the replicative DNA polymerases at
frequencies of about 2 per kb, which makes them by far the most abundant form of potential …
frequencies of about 2 per kb, which makes them by far the most abundant form of potential …