Choices of chromatographic methods as stability indicating assays for pharmaceutical products: A review

YL Chew, MA Khor, YY Lim - Heliyon, 2021 - cell.com
Stability indicating assay describes a technique which is used to analyse the stability of drug
substance or active pharmaceutical ingredient (API) in bulk drug and pharmaceutical …

Determination of atenolol and trimetazidine in pharmaceutical tablets and human urine using a high performance liquid chromatography‐photo diode array detection …

W El-Alfy, OA Ismaiel, MY El-Mammli… - International journal of …, 2019 - Wiley Online Library
A simple RP‐HPLC‐PDA method for determination of atenolol (ATN) and trimetazidine
(TMZ) in human urine and tablets has been developed. Analytes were separated on a …

Researches on Detection of Related Substances in Drugs

J Qi, H Wang, L Dai, L Shi, Y Hao… - Current Pharmaceutical …, 2023 - benthamdirect.com
The production of drugs is very complicated. In the process of preparation and
transportation, mixing a small amount of reaction raw materials, intermediates, and storage …

[HTML][HTML] Highly Sensitive Trimetazidine Determination Using Composite Yttria-Stabilized Zirconia Doped with Titanium Oxide–Carbon Black Biosensor

M Suchanek, A Krakowska, B Paczosa-Bator, R Piech - Materials, 2024 - mdpi.com
A novel composite voltammetric biosensor has been developed for the first time, utilizing a
glassy carbon electrode modified with yttria-stabilized zirconia doped with titanium dioxide …

One‐pot synthesis of fluorescent nitrogen and sulfur–carbon quantum dots as a sensitive nanosensor for trimetazidine determination

F Belal, M Mabrouk, S Hammad, A Barseem… - …, 2021 - Wiley Online Library
Water‐soluble and highly stable N, S‐doped CQDs (N, S‐CQDs) were synthesized using a
low‐cost strategy with citric acid and thiosemicarbazide in one step for use as a fluorescent …

Identification and characterization of the human urinary metabolites of trimetazidine using liquid chromatography high resolution mass spectrometry, an anti-doping …

Y Yuan, X Zhao, H Wei, Q Fei, Y Xu, J Lu - Microchemical Journal, 2021 - Elsevier
Trimetazidine (TMZ) is a clinically effective anti-angina and anti-ischemic metabolic drug
used to treat chest pain. It can also improve the exercise capacity of athletes and has been …

[HTML][HTML] Selective determination of dimenhydrinate in presence of six of its related substances and potential impurities using a direct GC/MS method

TS Belal, KM Abdel-Hay, CR Clark - Journal of Advanced Research, 2016 - Elsevier
A novel simple, direct and selective gas chromatography–mass spectrometry (GC/MS)
procedure was developed for the determination of the antihistamine drug dimenhydrinate …

Voltammetric behavior of trimetazidine hydrochloride at pre-anodized carbon paste electrode and its determination in pharmaceutical formulations

S Fan, L Ji, G Mao, H Wang, Y Fang, J Duan… - International Journal of …, 2021 - Elsevier
A functional pre-anodized carbon paste electrode (PACPE) was prepared by 35 successive
cycles of scans between 1.0 V-1.8 V in 0.2 mol L-1 NaOH solution. The electrode reaction …

The first spectrofluorimetric approach for accurate determination of trimetazidine in its dosage forms: Application to content uniformity testing

ME Halim, MA Omar, NA Abdallah, DM Nagy - Spectrochimica Acta Part A …, 2020 - Elsevier
A novel sensitive and simple spectrofluorimetric method has been developed then validated
for the determination of trimetazidine in pure form and its tablets. This method is found on the …

Factor optimization study to develop and validate a reversed-phase thin-layer chromatography method for the determination of trimetazidine dihydrochloride and its …

SM Soliman - JPC–Journal of Planar Chromatography–Modern TLC, 2019 - Springer
A validated reversed-phase thin-layer chromatography (RP-TLC)—densitometry method
was developed and optimized for the determination of trimetazidine dihydrochloride (TMZ) …