As a point of convergence for numerous oncogenic signaling pathways, signal transducer
and activator of transcription 3 (STAT3) is central in regulating the anti-tumor immune …

Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that
regulates various biological processes, including proliferation, metastasis, angiogenesis …

Abstract The Signal Transducer and Activator of Transcription 3 (STAT3) protein is encoded
on chromosome 17q21. The SH2 and the DNA binding domains are critical structural …

Formononetin, an isoflavone, is extracted from various medicinal plants and herbs, including
the red clover (Trifolium pratense) and Chinese medicinal plant Astragalus membranaceus …

Cancer is one of the greatest causes of death worldwide. With the development of surgery,
radiotherapy, and medical agents, the outcomes of cancer patients have greatly improved …

Breast cancer (BC) is one of the most common cancers in women. TNBC (Triple-negative
breast cancer) has limited treatment options and still lacks viable molecular targets, leading …

Abstract Di (2-ethylhexyl) phthalate (DEHP) is a known environmental endocrine disruptor
that impairs development of testis and spermatogenesis. This study aims to explore the …

Incorporation of heterocycles into drug molecules can enhance physical properties and
biological activity. A variety of heterocyclic groups is available to medicinal chemists, many …

The utilization of proximity-mediated effects to perturb pathogenic proteins of interest (POIs)
has emerged as a powerful strategic alternative to conventional drug design approaches …

Excessive activation of signal transducer and activator of transcription 3 (STAT3) is
implicated in breast cancer (BC) chemoresistance, but its underlying mechanism is not fully …