Recent advances in systems and synthetic biology approaches for developing novel cell-factories in non-conventional yeasts

P Patra, M Das, P Kundu, A Ghosh - Biotechnology Advances, 2021 - Elsevier
Microbial bioproduction of chemicals, proteins, and primary metabolites from cheap carbon
sources is currently an advancing area in industrial research. The model yeast …

[HTML][HTML] Kluyveromyces marxianus as a microbial cell factory for lignocellulosic biomass valorisation

M Baptista, L Domingues - Biotechnology Advances, 2022 - Elsevier
The non-conventional yeast Kluyveromyces marxianus is widely used for several
biotechnological applications, mainly due to its thermotolerance, high growth rate, and …

Reconstruction of a catalogue of genome-scale metabolic models with enzymatic constraints using GECKO 2.0

I Domenzain, B Sánchez, M Anton… - Nature …, 2022 - nature.com
Genome-scale metabolic models (GEMs) have been widely used for quantitative exploration
of the relation between genotype and phenotype. Streamlined integration of enzyme …

Genome-scale modeling of yeast metabolism: retrospectives and perspectives

Y Chen, F Li, J Nielsen - FEMS Yeast Research, 2022 - academic.oup.com
Yeasts have been widely used for production of bread, beer and wine, as well as for
production of bioethanol, but they have also been designed as cell factories to produce …

Kluyveromyces marxianus: a potential biocatalyst of renewable chemicals and lignocellulosic ethanol production

LV Leonel, PV Arruda, AK Chandel… - Critical Reviews in …, 2021 - Taylor & Francis
Kluyveromyces marxianus is an ascomycetous yeast which has shown promising results in
cellulosic ethanol and renewable chemicals production. It can survive on a variety of carbon …

Unraveling the potential of non-conventional yeasts in biotechnology

C Geijer, R Ledesma-Amaro… - FEMS Yeast …, 2022 - academic.oup.com
Cost-effective microbial conversion processes of renewable feedstock into biofuels and
biochemicals are of utmost importance for the establishment of a robust bioeconomy …

Pentose metabolism and conversion to biofuels and high-value chemicals in yeasts

J Ruchala, AA Sibirny - FEMS Microbiology Reviews, 2021 - academic.oup.com
Pentose sugars are widespread in nature and two of them, D-xylose and L-arabinose
belong to the most abundant sugars being the second and third by abundance sugars in dry …

Multiscale models quantifying yeast physiology: towards a whole-cell model

H Lu, EJ Kerkhoven, J Nielsen - Trends in Biotechnology, 2022 - cell.com
The yeast Saccharomyces cerevisiae is widely used as a cell factory and as an important
eukaryal model organism for studying cellular physiology related to human health and …

Kluyveromyces as promising yeast cell factories for industrial bioproduction: From bio-functional design to applications

Y Qiu, P Lei, R Wang, L Sun, Z Luo, S Li, H Xu - Biotechnology Advances, 2023 - Elsevier
As the two most widely used Kluyveromyces yeast, Kluyveromyces marxianus and K. lactis
have gained increasing attention as microbial chassis in biocatalysts, biomanufacturing and …

[HTML][HTML] Model-driven insights into the effects of temperature on metabolism

P Wendering, Z Nikoloski - Biotechnology Advances, 2023 - Elsevier
Temperature affects cellular processes at different spatiotemporal scales, and identifying the
genetic and molecular mechanisms underlying temperature responses paves the way to …