Interstitial cells of Cajal and human colon motility in health and disease

JD Huizinga, A Hussain… - American Journal of …, 2021 - journals.physiology.org
Our understanding of human colonic motility, and autonomic reflexes that generate motor
patterns, has increased markedly through high-resolution manometry. Details of the motor …

The gastric conduction system in health and disease: a translational review

G O'Grady, AA Gharibans, P Du… - American Journal of …, 2021 - journals.physiology.org
Gastric peristalsis is critically dependent on an underlying electrical conduction system.
Recent years have witnessed substantial progress in clarifying the operations of this system …

A mechanical wave travels along a genetic guide to drive the formation of an epithelial furrow during Drosophila gastrulation

A Popkova, U Andrenšek, S Pagnotta, P Ziherl… - Developmental Cell, 2024 - cell.com
Epithelial furrowing is a fundamental morphogenetic process during gastrulation,
neurulation, and body shaping. A furrow often results from a fold that propagates along a …

The cyclic motor patterns in the human colon

M Pervez, E Ratcliffe, SP Parsons… - …, 2020 - Wiley Online Library
Background High‐resolution colonic manometry gives an unprecedented window into motor
patterns of the human colon. Our objective was to characterize motor activities throughout …

Shifting into high gear: how interstitial cells of Cajal change the motility pattern of the developing intestine

NR Chevalier, Y Ammouche, A Gomis… - American Journal …, 2020 - journals.physiology.org
The first contractile waves in the developing embryonic gut are purely myogenic; they only
involve smooth muscle. Here, we provide evidence for a transition from smooth muscle to …

Nitric oxide is essential for generating the minute rhythm contraction pattern in the small intestine, likely via ICC-DMP

SP Parsons, JD Huizinga - Frontiers in Neuroscience, 2021 - frontiersin.org
Nitrergic nerves have been proposed to play a critical role in the orchestration of peristaltic
activities throughout the gastrointestinal tract. In the present study, we investigated the role …

Measurement and Analysis of In Vivo Gastroduodenal Slow Wave Patterns Using Anatomically-Specific Cradles and Electrodes

S Simmonds, LK Cheng, WW Ruha… - IEEE Transactions …, 2023 - ieeexplore.ieee.org
Objective: Bioelectrical 'slow waves' regulate gastrointestinal contractions. We aimed to
confirm whether the pyloric sphincter demarcates slow waves in the intact stomach and …

Dynamic slow‐wave interactions in the rabbit small intestine defined using high‐resolution mapping

A Cherian Abraham, LK Cheng… - …, 2019 - Wiley Online Library
Background The motility in the small intestine is governed in part by myogenic bio‐electrical
events, known as slow waves. High‐resolution multi‐electrode mapping has improved our …

An update on pacemaking in the myometrium

S Wray, MJ Taggart - The Journal of Physiology, 2024 - Wiley Online Library
Timely and efficient contractions of the smooth muscle of the uterus–the myometrium–are
crucial to a successful pregnancy outcome. These episodic contractions are regulated by …

Electromechanical Coupling and Anatomy of the In-Vivo Gastroduodenal Junction

S Simmonds, A Matthee, JM Dowrick… - American Journal …, 2024 - journals.physiology.org
Introduction: Few biomarkers support diagnosis and treatment of disorders of gut-brain
interaction (DGBI), although gastroduodenal junction (GDJ) electromechanical coupling is a …