RNA–DNA hybrids are generated during transcription, DNA replication and DNA repair and
are crucial intermediates in these processes. When RNA–DNA hybrids are stably formed in …

Although transcription is an essential cellular process, it is paradoxically also a well-
recognized cause of genomic instability. R-loops, non-B DNA structures formed when …

The single-stranded DNA cytosine-to-uracil deaminase APOBEC3B is an antiviral protein
implicated in cancer. However, its substrates in cells are not fully delineated. Here …

Eukaryotic cells deploy overlapping repair pathways to resolve DNA damage.
Advancements in genome editing take advantage of these pathways to produce permanent …

During transcription, the nascent RNA strand can base pair with its template DNA, displacing
the non-template strand as ssDNA and forming a structure called an R-loop. R-loops are …

DNA-RNA hybrids play a physiological role in cellular processes, but often, they represent
non-scheduled co-transcriptional structures with a negative impact on transcription …

Genome instability, defined as higher than normal rates of mutation, is a double-edged
sword. As a source of genetic diversity and natural selection, mutations are beneficial for …

Conflicts between transcription and replication are a potent source of DNA damage. Co-
transcriptional R-loops could aggravate such conflicts by creating an additional barrier to …

Genomic maps of DNA G-quadruplexes (G4s) can help elucidate the roles that these
secondary structures play in various organisms. Herein, we employ an improved version of a …

Focal copy-number amplification is an oncogenic event. Although recent studies have
revealed the complex structure,–and the evolutionary trajectories of oncogene amplicons …