ERK: a double-edged sword in cancer. ERK-dependent apoptosis as a potential therapeutic strategy for cancer
R Sugiura, R Satoh, T Takasaki - Cells, 2021 - mdpi.com
The RAF/MEK/ERK signaling pathway regulates diverse cellular processes as exemplified
by cell proliferation, differentiation, motility, and survival. Activation of ERK1/2 generally …
by cell proliferation, differentiation, motility, and survival. Activation of ERK1/2 generally …
ERK pathway agonism for cancer therapy: evidence, insights, and a target discovery framework
At least 40% of human cancers are associated with aberrant ERK pathway activity (ERKp).
Inhibitors targeting various effectors within the ERKp have been developed and explored for …
Inhibitors targeting various effectors within the ERKp have been developed and explored for …
[HTML][HTML] Inhibition of ERO1L induces autophagy and apoptosis via endoplasmic reticulum stress in colorectal cancer
P Chen, Y Chen, A Sharma, AGC Maria… - Cellular …, 2025 - Elsevier
Colorectal cancer (CRC) is one of the most common types of cancer with high incidence and
mortality. Endoplasmic reticulum oxidoreductase 1 alpha (ERO1L) is overexpressed in CRC …
mortality. Endoplasmic reticulum oxidoreductase 1 alpha (ERO1L) is overexpressed in CRC …
[HTML][HTML] ACAGT-007a, an ERK MAPK signaling modulator, in combination with AKT signaling inhibition induces apoptosis in kras mutant pancreatic cancer T3M4 and …
GI Khandakar, R Satoh, T Takasaki, K Fujitani… - Cells, 2022 - mdpi.com
The mitogen-activated protein kinase (MAPK)/ERK and phosphatidylinositol-3 kinase
(PI3K)/AKT pathways are dysregulated in various human cancers, including pancreatic …
(PI3K)/AKT pathways are dysregulated in various human cancers, including pancreatic …
ACA‐28, an ERK MAPK Signaling Modulator, Exerts Anticancer Activity through ROS Induction in Melanoma and Pancreatic Cancer Cells
T Takasaki, Y Hamabe, K Touchi… - Oxidative Medicine …, 2024 - Wiley Online Library
The extracellular signal‐regulated kinase (ERK) MAPK pathway is dysregulated in various
human cancers and is considered an attractive therapeutic target for cancer. Therefore …
human cancers and is considered an attractive therapeutic target for cancer. Therefore …
The MEK 1/2 inhibitor PD98059 exhibits synergistic anti-endometrial cancer activity with paclitaxel in vitro and enhanced tissue distribution in vivo when formulated …
K Wiwatchaitawee, AI Mekkawy, JC Quarterman… - Drug delivery and …, 2021 - Springer
Endometrial cancer is the most common gynecological cancer that affects the female
reproductive organs. The standard therapy for EC for the past two decades has been …
reproductive organs. The standard therapy for EC for the past two decades has been …
[PDF][PDF] Synthesis of benzhydrol analogues based on 1´-acetoxychavicol acetate (ACA), as a stable and potent antiproliferative agent on breast cancer cell lines …
MN Azmi, CS Tan, HT Abdulameed… - Organic …, 2024 - acgpubs.org
Six benzhydrol analogues were successfully synthesised and evaluated for their
antiproliferative effect on breast cancer cells. These compounds were designed based on …
antiproliferative effect on breast cancer cells. These compounds were designed based on …
ACAGT‐007a, an anti‐cancer compound that modulates ERK MAPK signaling, induces nuclear enrichment of phosphorylated ERK in T3M4 pancreatic cancer cells
GI Khandakar, Y Miyamoto, R Satoh… - Genes to …, 2023 - Wiley Online Library
The extracellular‐signal‐regulated‐kinase (ERK) signaling pathway is essential for cell
proliferation and is frequently deregulated in human tumors such as pancreatic cancers …
proliferation and is frequently deregulated in human tumors such as pancreatic cancers …
[PDF][PDF] Department of Bioresources School of Biological Sciences
U Mehraj - 2022 - researchgate.net
The copy of this thesis has been supplied on the condition that anyone who consults it, is
understood to recognize that the copyright of this work rests with the author, namely Mr Umar …
understood to recognize that the copyright of this work rests with the author, namely Mr Umar …