Endothelial activation and dysfunction in COVID-19: from basic mechanisms to potential therapeutic approaches

Y Jin, W Ji, H Yang, S Chen, W Zhang… - Signal transduction and …, 2020 - nature.com
On 12 March 2020, the outbreak of coronavirus disease 2019 (COVID-19) was declared a
pandemic by the World Health Organization. As of 4 August 2020, more than 18 million …

Endothelial dysfunction and platelet hyperactivity in type 2 diabetes mellitus: molecular insights and therapeutic strategies

R Kaur, M Kaur, J Singh - Cardiovascular diabetology, 2018 - Springer
The incidence and prevalence of diabetes mellitus is rapidly increasing worldwide at an
alarming rate. Type 2 diabetes mellitus (T2DM) is the most prevalent form of diabetes …

Endothelial dysfunction and hypertension

D Konukoglu, H Uzun - Hypertension: from basic research to clinical …, 2017 - Springer
In the past, endothelium was thought to be only a mechanical barrier. Today, endothelium is
known to be a tissue regulating vascular tone, cell growth and the interaction between the …

[HTML][HTML] Biomarkers of endothelial activation and dysfunction in cardiovascular diseases

J Zhang - Reviews in cardiovascular medicine, 2022 - imrpress.com
Endothelial activation and dysfunction is an important contributor to atherosclerosis,
cardiovascular diseases and cardiorenal syndrome. Endothelial dysfunction is also linked …

The role of cytokines in the development of atherosclerosis

AR Fatkhullina, IO Peshkova, EK Koltsova - Biochemistry (Moscow), 2016 - Springer
Atherosclerosis contributes to the development of many cardiovascular diseases, which
remain the leading cause of death in developed countries. Atherosclerosis is a chronic …

Endothelial dysfunction: the early predictor of atherosclerosis

M Mudau, A Genis, A Lochner… - Cardiovascular journal of …, 2012 - journals.co.za
Since the discovery in the 1980s that nitric oxide (NO) is in fact the elusive endothelium-
derived relaxing factor, it has become evident that NO is not only a major cardiovascular …

The pathophysiology of SARS-CoV-2: A suggested model and therapeutic approach

G Morris, CC Bortolasci, BK Puri, L Olive, W Marx… - Life sciences, 2020 - Elsevier
In this paper, a model is proposed of the pathophysiological processes of COVID-19 starting
from the infection of human type II alveolar epithelial cells (pneumocytes) by SARS-CoV-2 …

Inflammatory cytokines in vascular dysfunction and vascular disease

AH Sprague, RA Khalil - Biochemical pharmacology, 2009 - Elsevier
The vascular inflammatory response involves complex interaction between inflammatory
cells (neutrophils, lymphocytes, monocytes, macrophages), endothelial cells (ECs), vascular …

Relation between red blood cell distribution width and inflammatory biomarkers in a large cohort of unselected outpatients

G Lippi, G Targher, M Montagnana… - … of pathology & …, 2009 - meridian.allenpress.com
Context.—A strong independent association has been recently observed between elevated
red blood cell distribution width (RDW) and increased incidence of cardiovascular events …

Vascularization strategies for tissue engineering

M Lovett, K Lee, A Edwards… - Tissue Engineering Part B …, 2009 - liebertpub.com
Tissue engineering is currently limited by the inability to adequately vascularize tissues in
vitro or in vivo. Issues of nutrient perfusion and mass transport limitations, especially oxygen …