The maintenance of a healthy and functional mitochondrial network is critical during
development as well as throughout life in the response to physiological adaptations and …

Myocardial infarction (MI) is the irreversible death of cardiomyocyte secondary to prolonged
lack of oxygen or fresh blood supply. Historically considered as merely cardiomyocyte …

Mitochondria contain their own genetic system and undergo a unique mode of cytoplasmic
inheritance. Each organelle has multiple copies of a covalently closed circular DNA genome …

Gene regulatory factors encoded by the nuclear genome are essential for mitochondrial
biogenesis and function. Some of these factors act exclusively within the mitochondria to …

Mitochondria play central roles in energy homeostasis, metabolism, signaling, and
apoptosis. Accordingly, the abundance, morphology, and functional properties of …

Mitochondria are highly dynamic organelles of crucial importance to the proper functioning
of neuronal, cardiac and other cell types dependent upon aerobic efficiency. Mitochondrial …

Mitochondria play a central role in the pathophysiological processes of acute ischemic
stroke. Disruption of the cerebral blood flow during acute ischemic stroke interrupts oxygen …

In the developing and mature brain, mitochondria act as central hubs for distinct but
interwined pathways, necessary for neural development, survival, activity, connectivity and …

Expression of the respiratory apparatus depends on both nuclear and mitochondrial genes.
Although these genes are sequestered in distinct cellular organelles, their transcription …

There has been increasing evidence pointing to the mitochondrial respiratory chain (MRC)
as a novel and important target for the actions of 17β-estradiol (E2) and estrogen receptors …