Complement has long been considered a key innate immune effector system that mediates
host defence and tissue homeostasis. Yet, growing evidence has illuminated a broader …

RNA therapeutics show a significant breakthrough for the treatment of otherwise incurable
diseases and genetic disorders by regulating disease-related gene expression. The …

Background Geographic atrophy is an advanced form of dry age-related macular
degeneration that can lead to irreversible vision loss and high burden of disease. We aimed …

C3 is the central effector molecule of the complement system, mediating its multiple
functions through different binding sites and their corresponding receptors. We will introduce …

Background Some clinical features of severe COVID-19 represent blood vessel damage
induced by activation of host immune responses initiated by the coronavirus SARS-CoV-2 …

The complement cascade is a key component of the innate immune system that is rapidly
recruited through a cascade of enzymatic reactions to enable the recognition and clearance …

The complement system is involved in the pathogenesis of several ocular diseases,
providing a rationale for the investigation of complement-targeting therapeutics for these …

Neuromyelitis optica spectrum disorder (NMOSD) is a rare relapsing neuroinflammatory
autoimmune astrocytopathy, with a predilection for the optic nerves and spinal cord. Most …

The membrane attack complex—also known as C5b-9—is the end-product of the classical,
lectin, and alternative complement pathways. It is thought to play an important role in the …

Age-related macular degeneration (AMD) remains a major cause of legal blindness, and
treatment for the geographic atrophy form of AMD is a significant unmet need. Dysregulation …