Molecular mechanisms of high-altitude acclimatization

RT Mallet, J Burtscher, V Pialoux, Q Pasha… - International journal of …, 2023 - mdpi.com
High-altitude illnesses (HAIs) result from acute exposure to high altitude/hypoxia. Numerous
molecular mechanisms affect appropriate acclimatization to hypobaric and/or normobaric …

Physiological and biological responses to short-term intermittent hypobaric hypoxia exposure: from sports and mountain medicine to new biomedical applications

G Viscor, JR Torrella, L Corral, A Ricart… - Frontiers in …, 2018 - frontiersin.org
In recent years, the altitude acclimatization responses elicited by short-term intermittent
exposure to hypoxia have been subject to renewed attention. The main goal of short-term …

Contemporary periodization of altitude training for elite endurance athletes: a narrative review

I Mujika, AP Sharma, T Stellingwerff - Sports medicine, 2019 - Springer
Since the 1960s there has been an escalation in the purposeful utilization of altitude to
enhance endurance athletic performance. This has been mirrored by a parallel …

A systematic review examining the approaches used to estimate interindividual differences in trainability and classify individual responses to exercise training

JT Bonafiglia, N Preobrazenski, BJ Gurd - Frontiers in physiology, 2021 - frontiersin.org
Background: Many reports describe statistical approaches for estimating interindividual
differences in trainability and classifying individuals as “responders” or “non-responders.” …

Time for a new metric for hypoxic dose?

LA Garvican-Lewis, K Sharpe… - Journal of Applied …, 2016 - journals.physiology.org
THE OPTIMAL HYPOXIC DOSE for sea level performance adaptation is not a new concept.
Too long and/or too extreme exposure and training/performance is compromised, whereas …

CrossTalk proposal: Barometric pressure, independent of PO2, is the forgotten parameter in altitude physiology and mountain medicine

GP Millet, T Debevec - J Physiol, 2020 - Wiley Online Library
The equivalent air altitude model, often employed in altitude medicine research and
interventional settings, stipulates that different combinations of barometric pressure (PB) and …

Hypoxic training is beneficial in elite athletes

GP Millet, F Brocherie - Medicine and science in sports and …, 2020 - insep.hal.science
There is no doubt that many hypoxic conditions or prolonged exposures to altitude result in
“biological costs of hypoxic adaptations that outweigh their benefits”(1), particularly in …

CORP: The assessment of total hemoglobin mass by carbon monoxide rebreathing

C Siebenmann, S Keiser, P Robach… - Journal of Applied …, 2017 - journals.physiology.org
In this Cores of Reproducibility in Physiology (CORP) article, we present the theory and
practical aspects of the carbon monoxide (CO) rebreathing method for the determination of …

High-Altitude Andean H194R HIF2A Allele Is a Hypomorphic Allele

K Jorgensen, D Song, J Weinstein… - Molecular biology …, 2023 - academic.oup.com
Abstract For over 10,000 years, Andeans have resided at high altitude where the partial
pressure of oxygen challenges human survival. Recent studies have provided evidence for …

Prevalence estimate of blood doping in elite track and field athletes during two major international events

R Faiss, J Saugy, A Zollinger, N Robinson… - Frontiers in …, 2020 - frontiersin.org
In elite sport, the Athlete Biological Passport (ABP) was invented to tackle cheaters by
monitoring closely changes in biological parameters, flagging atypical variations. The …