Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread in
humans in almost every country, causing the disease COVID-19. Since the start of the …

The majority of cancer-associated deaths are related to secondary tumor formation. This
multistep process involves the migration of cancer cells to anatomically distant organs …

The field of membrane protein structural biology has been revolutionized over the last few
years with a number of high profile structures being solved using cryo-EM including Piezo …

There is considerable interest in the development of membrane mimetics to study the
structure, dynamics and function of membrane proteins. Polymer nanodiscs have been …

Transmembrane protein (TMEM) is a family of protein that spans cytoplasmic membranes
and allows cell–cell and cell–environment communication. Dysregulation of TMEMs has …

For mechanical force to induce changes in cellular behaviors, two main processes are
inevitable; perception of the force and response to it. Perception of mechanical force by …

The aliphatic hydrophobic amino acid residues—alanine, isoleucine, leucine, proline and
valine—are among the most common found in proteins. Their structural role in proteins is …

All intact cells, and their organelles, are surrounded by a∼ 30 Å hydrophobic film that
typically separates the interior from the environment. This film is composed of lipid bilayers …

Drug-resistant epileptic encephalopathies of infancy have been associated with KCNT1 gain-
of-function mutations, which increase the activity of K Na 1.1 sodium-activated potassium …

Biological membranes define and determine the architecture, ie, shape, of cells and
organelles. While most membranes present a planar morphology on the nanometer length …