Mitochondrial dysfunction in neurodegenerative diseases and drug targets via apoptotic signaling

Y Wu, M Chen, J Jiang - Mitochondrion, 2019 - Elsevier
Mitochondrial dysfunction is becoming one of the most emerging pathological process in the
etiology of neurological disorders. Other common etiologies of the neurological disorders …

Mitochondrial calcium: effects of its imbalance in disease

D Matuz-Mares, M González-Andrade… - Antioxidants, 2022 - mdpi.com
Calcium is used in many cellular processes and is maintained within the cell as free calcium
at low concentrations (approximately 100 nM), compared with extracellular (millimolar) …

Clinical and preclinical perspectives on Chemotherapy-Induced Peripheral Neuropathy (CIPN): a narrative review

SJL Flatters, PM Dougherty… - BJA: British Journal of …, 2017 - academic.oup.com
This review provides an update on the current clinical and preclinical understanding of
chemotherapy induced peripheral neuropathy (CIPN). The overview of the clinical syndrome …

Antioxidant therapeutic strategies in neurodegenerative diseases

C Morén, RM deSouza, DM Giraldo, C Uff - International journal of …, 2022 - mdpi.com
The distinguishing pathogenic features of neurodegenerative diseases include
mitochondrial dysfunction and derived reactive oxygen species generation. The neural …

[HTML][HTML] Macrophages transfer mitochondria to sensory neurons to resolve inflammatory pain

M van der Vlist, R Raoof, HLDM Willemen, J Prado… - Neuron, 2022 - cell.com
The current paradigm is that inflammatory pain passively resolves following the cessation of
inflammation. Yet, in a substantial proportion of patients with inflammatory diseases …

Mechanisms underlying paclitaxel-induced neuropathic pain: Channels, inflammation and immune regulations

Y Xu, Z Jiang, X Chen - European Journal of Pharmacology, 2022 - Elsevier
Paclitaxel is a chemotherapeutic agent widely used for many types of malignancies.
However, when paclitaxel is used to treat tumors, patients commonly experience severe …

Modulation of Diabetes-Induced Oxidative Stress, Apoptosis, and Ca2+ Entry Through TRPM2 and TRPV1 Channels in Dorsal Root Ganglion and Hippocampus of …

MC Kahya, M Nazıroğlu, İS Övey - Molecular neurobiology, 2017 - Springer
Neuropathic pain and hippocampal injury can arise from the overload of diabetes-induced
calcium ion (Ca 2+) entry and oxidative stress. The transient receptor potential (TRP) …

Voluntary wheel running delays disease onset and reduces pain hypersensitivity in early experimental autoimmune encephalomyelitis (EAE)

C Benson, JW Paylor, G Tenorio, I Winship… - Experimental …, 2015 - Elsevier
Multiple sclerosis (MS) is classically defined by motor deficits, but it is also associated with
the secondary symptoms of pain, depression, and anxiety. Up to this point modifying these …

Mitochondrial dysfunction in diabetic neuropathy: a series of unfortunate metabolic events

P Fernyhough - Current diabetes reports, 2015 - Springer
Diabetic neuropathy is a dying back neurodegenerative disease of the peripheral nervous
system where mitochondrial dysfunction has been implicated as an etiological factor …

Nociceptor translational profiling reveals the Ragulator-Rag GTPase complex as a critical generator of neuropathic pain

S Megat, PR Ray, JK Moy, TF Lou… - Journal of …, 2019 - Soc Neuroscience
Nociceptors, sensory neurons in the DRG that detect damaging or potentially damaging
stimuli, are key drivers of neuropathic pain. Injury to these neurons causes activation of …