Germinal center and extrafollicular B cell responses in vaccination, immunity, and autoimmunity
RA Elsner, MJ Shlomchik - Immunity, 2020 - cell.com
Activated B cells participate in either extrafollicular (EF) or germinal center (GC) responses.
Canonical responses are composed of a short wave of plasmablasts (PBs) arising from EF …
Canonical responses are composed of a short wave of plasmablasts (PBs) arising from EF …
Dendritic cell regulation of T helper cells
As the professional antigen-presenting cells of the immune system, dendritic cells (DCs)
sense the microenvironment and shape the ensuing adaptive immune response. DCs can …
sense the microenvironment and shape the ensuing adaptive immune response. DCs can …
Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses
Adjuvants are critical for improving the quality and magnitude of adaptive immune
responses to vaccination. Lipid nanoparticle (LNP)-encapsulated nucleoside-modified …
responses to vaccination. Lipid nanoparticle (LNP)-encapsulated nucleoside-modified …
Neoantigen-driven B cell and CD4 T follicular helper cell collaboration promotes anti-tumor CD8 T cell responses
Summary CD4 T follicular helper (TFH) cells support B cells, which are critical for germinal
center (GC) formation, but the importance of TFH-B cell interactions in cancer is unclear. We …
center (GC) formation, but the importance of TFH-B cell interactions in cancer is unclear. We …
In Vivo CD4+ T Cell Differentiation and Function: Revisiting the Th1/Th2 Paradigm
M Ruterbusch, KB Pruner, L Shehata… - Annual review of …, 2020 - annualreviews.org
The discovery of CD4+ T cell subset–defining master transcription factors and framing of the
Th1/Th2 paradigm ignited the CD4+ T cell field. Advances in in vivo experimental systems …
Th1/Th2 paradigm ignited the CD4+ T cell field. Advances in in vivo experimental systems …
Monocyte differentiation and antigen-presenting functions
Monocytes develop in the bone marrow and represent the primary type of mononuclear
phagocyte found in the blood. They were long thought of as a source for tissue …
phagocyte found in the blood. They were long thought of as a source for tissue …
The immunobiology of the interleukin-12 family: room for discovery
The discovery of interleukin (IL)-6 and its receptor subunits provided a foundation to
understand the biology of a group of related cytokines: IL-12, IL-23, and IL-27. These family …
understand the biology of a group of related cytokines: IL-12, IL-23, and IL-27. These family …
Human blood CXCR5+ CD4+ T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion
R Morita, N Schmitt, SE Bentebibel, R Ranganathan… - Immunity, 2011 - cell.com
Although a fraction of human blood memory CD4+ T cells expresses chemokine (CXC motif)
receptor 5 (CXCR5), their relationship to T follicular helper (Tfh) cells is not well established …
receptor 5 (CXCR5), their relationship to T follicular helper (Tfh) cells is not well established …
Follicular Helper CD4 T Cells (TFH)
S Crotty - Annual review of immunology, 2011 - annualreviews.org
T cell help to B cells is a fundamental aspect of adaptive immunity and the generation of
immunological memory. Follicular helper CD4 T (TFH) cells are the specialized providers of …
immunological memory. Follicular helper CD4 T (TFH) cells are the specialized providers of …
Induction of ICOS+CXCR3+CXCR5+ TH Cells Correlates with Antibody Responses to Influenza Vaccination
SE Bentebibel, S Lopez, G Obermoser… - Science translational …, 2013 - science.org
Seasonal influenza vaccine protects 60 to 90% of healthy young adults from influenza
infection. The immunological events that lead to the induction of protective antibody …
infection. The immunological events that lead to the induction of protective antibody …