Chronic pain is a refractory health disease worldwide causing an enormous economic
burden on individuals and society. Accumulating evidence suggests that inflammation in the …

Chronic pain is a prevalent condition with a multifaceted pathogenesis, where epigenetic
modifications, particularly DNA methylation, might play an important role. This review delves …

Enhancer of zeste homolog 2 (EZH2) mediates the trimethylation of histone 3 lysine 27
(H3K27) to promote gene silencing. Inhibition of EZH2 is a viable strategy for cancer …

Visceral pain is among the most prevalent and bothersome forms of chronic pain, but their
transmission in the spinal cord is still poorly understood. Here, we conducted focal colorectal …

Irritable bowel syndrome (IBS) related chronic visceral pain affects 20% of people
worldwide. The treatment options are very limited. Although the scholarly reviews have …

Chronic visceral pain is a common symptom of irritable bowel syndrome (IBS). Exosomes
are involved in the development of pain. Rab27a can mediate the release of exosomes. The …

Aims Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder, but its
pathogenesis remains incompletely understood, particularly the involvements of central …

Abstract Background The P2X7 receptor (P2X7R) is known to play a significant role in
regulating various pathological processes associated with immune regulation …

Chronic visceral pain stems from internal organs and is frequently associated with functional
gastrointestinal disorders, like irritable bowel syndrome (IBS). Since the underlying …

Irritable bowel syndrome (IBS) is a prevalent functional gastrointestinal disease
characterized by chronic visceral pain with a complex etiology and challenging treatment …