The recent advent of human pluripotent stem cell (PSC)-derived 3D brain organoids has
opened a window into aspects of human brain development that were not accessible before …

It has recently emerged that microglia, the tissue-resident macrophages of the central
nervous system, play significant non-innate immune roles to support the development …

While inner ear disorders are common, our ability to intervene and recover their sensory
function is limited. In vitro models of the inner ear, like the organoid system, could aid in …

Microglia have fundamental roles in health and disease; however, effects of age, sex, and
genetic factors on human microglia have not been fully explored. We applied bulk and …

Alzheimer's disease (AD) is a devastating neurodegenerative disorder affecting the aging
population. Despite many studies, there remains an urgent need to identify the root causes …

Advancements in human pluripotent stem cell technology offer a unique opportunity for the
neuroimmunology field to study host–virus interactions directly in disease-relevant cells of …

Despite their large societal burden, the development of therapeutic treatments for
neurodegenerative diseases (NDDs) has been relatively unsuccessful. This is, in part, due …

Induced pluripotent stem cells (iPSCs) are a self-renewable pool of cells derived from an
organism's somatic cells. These can then be programmed to other cell types, including …

Human pluripotent stem cells can be differentiated into cell types that are representative of
the central nervous system. Under specific culture conditions, these cells can be induced to …

Microglia are resident immune cells in the central nervous system (CNS). Microglia exhibit
diversity in their morphology, density, electrophysiological properties, and gene expression …