Autophagy and Alzheimer's disease: from molecular mechanisms to therapeutic implications

MS Uddin, A Stachowiak, AA Mamun… - Frontiers in aging …, 2018 - frontiersin.org
Alzheimer's disease (AD) is the most common cause of progressive dementia in the elderly.
It is characterized by a progressive and irreversible loss of cognitive abilities and formation …

The endocannabinoid system and eating behaviours: a review of the current state of the evidence

N Aguilera Vasquez, DE Nielsen - Current Nutrition Reports, 2022 - Springer
Abstract Purpose of the Review The endocannabinoid system (ENS) has emerged as an
important factor in food intake and may have implications for nutrition research. The …

Cannabidiol is a negative allosteric modulator of the cannabinoid CB1 receptor

RB Laprairie, AM Bagher, MEM Kelly… - British journal of …, 2015 - Wiley Online Library
Background and Purpose Cannabidiol has been reported to act as an antagonist at
cannabinoid CB1 receptors. We hypothesized that cannabidiol would inhibit cannabinoid …

Rising stars: Modulation of brain functions by astroglial type‐1 cannabinoid receptors

M Metna‐Laurent, G Marsicano - Glia, 2015 - Wiley Online Library
The type‐1‐cannabinoid (CB1) receptor is amongst the most widely expressed G protein‐
coupled receptors in the brain. In few decades, CB1 receptors have been shown to regulate …

A peripheral endocannabinoid mechanism contributes to glucocorticoid-mediated metabolic syndrome

NP Bowles, IN Karatsoreos, X Li… - Proceedings of the …, 2015 - National Acad Sciences
Glucocorticoids are known to promote the development of metabolic syndrome through the
modulation of both feeding pathways and metabolic processes; however, the precise …

[HTML][HTML] Astroglial CB1 cannabinoid receptors regulate leptin signaling in mouse brain astrocytes

B Bosier, L Bellocchio, M Metna-Laurent… - Molecular …, 2013 - Elsevier
Abstract Type-1 cannabinoid (CB 1) and leptin (ObR) receptors regulate metabolic and
astroglial functions, but the potential links between the two systems in astrocytes were not …

Therapeutic potential of non-psychotropic cannabidiol in ischemic stroke

K Hayakawa, K Mishima, M Fujiwara - Pharmaceuticals, 2010 - mdpi.com
Cannabis contains the psychoactive component delta9-tetrahydrocannabinol (delta9-THC),
and the non-psychoactive components cannabidiol (CBD), cannabinol, and cannabigerol. It …

Second generation CB1 receptor blockers and other inhibitors of peripheral endocannabinoid overactivity and the rationale of their use against metabolic disorders

C Silvestri, V Di Marzo - Expert opinion on investigational drugs, 2012 - Taylor & Francis
Introduction: Excessive abdominal obesity along with other risk factors results in the
metabolic syndrome, which can lead to heart disease, Type-2 diabetes, and death. The …

The role of astrocytes in the hypothalamic response and adaptation to metabolic signals

JA Chowen, P Argente-Arizón, A Freire-Regatillo… - Progress in …, 2016 - Elsevier
The hypothalamus is crucial in the regulation of homeostatic functions in mammals, with the
disruption of hypothalamic circuits contributing to chronic conditions such as obesity …

Maternal deprivation and adolescent cannabinoid exposure impact hippocampal astrocytes, CB1 receptors and brain-derived neurotrophic factor in a sexually …

M López-Gallardo, AB López-Rodríguez… - Neuroscience, 2012 - Elsevier
We have recently reported that early maternal deprivation (MD) for 24 h [postnatal day
(PND) 9–10] and/or an adolescent chronic treatment with the cannabinoid agonist CP …