Dopamine (DA) is a critical neurotransmitter in the mammalian central nervous system
(CNS). The cerebral dopaminergic system is implicated in the pathophysiology of several …

Dopamine (DA) is known to play an important role in numerous brain functions and has
been suggested to be involved in several neuropsychiatric and neurological disorders. From …

New 3-azabicyclo [3.2. 0] heptane derivatives were synthesized using a multicomponent
reaction. Racemic compounds were efficiently resolved by kinetic resolution with …

The 2-fluoroalkoxy-substituted catechol-aporphines 6, 8a− f and 11-mono-
hydroxyaporphines 11a− e were synthesized and found to have high in vitro affinity and …

N-Methyllaurotetanine (1) has been reported to display good affinity for the 5-HT1A receptor,
but no structure–affinity studies have been performed to date. The commercially available …

Thebaine was converted into its iron tricarbonyl complex, which underwent successive N-
and O-demethylation with BrCN and BBr 3, respectively. Decomplexation of the iron …

The first total synthesis of (S)-(+)-ovigerine,(S)-(+)-N-formylovigerine, and (6aS, 6a'S)-(+)-
ovigeridimerine of aporphine alkaloids with a benzo [d][1, 3] dioxole structure feature was …

We synthesized several novel 2-O-or 11-O-substituted N-alkylnoraporphines and assessed
their affinities at dopamine D1 and D2, and serotonin 5-HT1A receptors in rat forebrain …

Two synthesis routes have been elaborated for the preparation of novel N-substituted-2-
alkyl-and 2-arylnorapomorphines. The first one utilizes the traditional methodology of N …

We synthesized several esters of R (−)-N-alkyl-11-hydroxy-2-methoxynoraporphines,
assessed their affinities at dopamine D1 and D2 receptors in rat forebrain tissue and …