ADP-ribosylation from molecular mechanisms to therapeutic implications
ADP-ribosylation is a ubiquitous modification of biomolecules, including proteins and
nucleic acids, that regulates various cellular functions in all kingdoms of life. The recent …
nucleic acids, that regulates various cellular functions in all kingdoms of life. The recent …
Immunomodulatory roles of PARPs: Shaping the tumor microenvironment, one ADP-ribose at a time
PARPs encompass a small yet pervasive group of 17 enzymes that catalyze a post-
translational modification known as ADP-ribosylation. PARP1, the founding member, has …
translational modification known as ADP-ribosylation. PARP1, the founding member, has …
Updated protein domain annotation of the PARP protein family sheds new light on biological function
MJ Suskiewicz, D Munnur, Ø Strømland… - Nucleic Acids …, 2023 - academic.oup.com
AlphaFold2 and related computational tools have greatly aided studies of structural biology
through their ability to accurately predict protein structures. In the present work, we explored …
through their ability to accurately predict protein structures. In the present work, we explored …
Positive selection analyses identify a single WWE domain residue that shapes ZAP into a more potent restriction factor against alphaviruses
S Huang, J Girdner, LAP Nguyen, C Sandoval… - Plos …, 2024 - journals.plos.org
The host interferon pathway upregulates intrinsic restriction factors in response to viral
infection. Many of them block a diverse range of viruses, suggesting that their antiviral …
infection. Many of them block a diverse range of viruses, suggesting that their antiviral …
Targeting the ubiquitin–proteasome system and recent advances in cancer therapy
D Spano, G Catara - Cells, 2023 - mdpi.com
Ubiquitination is a reversible post-translational modification based on the chemical addition
of ubiquitin to proteins with regulatory effects on various signaling pathways. Ubiquitination …
of ubiquitin to proteins with regulatory effects on various signaling pathways. Ubiquitination …
Versatility of the zinc-finger antiviral protein (ZAP) as a modulator of viral infections
The zinc-finger antiviral protein (ZAP) is a restriction factor that proficiently impedes the
replication of a variety of RNA and DNA viruses. In recent years, the affinity of ZAP's zinc …
replication of a variety of RNA and DNA viruses. In recent years, the affinity of ZAP's zinc …
Regulation of stress granule maturation and dynamics by poly (ADP-ribose) interaction with PARP13
SJ Cheng, T Gafaar, JRA Kuttiyatveetil… - Nature …, 2025 - nature.com
Non-covalent interactions of poly (ADP-ribose)(PAR) facilitate condensate formation, yet the
impact of these interactions on condensate properties remains unclear. Here, we …
impact of these interactions on condensate properties remains unclear. Here, we …
Iso-ADP-Ribose Fluorescence Polarization Probe for the Screening of RNF146 WWE Domain Inhibitors
Poly-ADP-ribosylation is an important protein post-translational modification with diverse
biological consequences. After binding poly-ADP-ribose on axis inhibition protein 1 (AXIN1) …
biological consequences. After binding poly-ADP-ribose on axis inhibition protein 1 (AXIN1) …
A ligand discovery toolbox for the WWE domain family of human E3 ligases
The WWE domain is a relatively under-researched domain found in twelve human proteins
and characterized by a conserved tryptophan-tryptophan-glutamate (WWE) sequence motif …
and characterized by a conserved tryptophan-tryptophan-glutamate (WWE) sequence motif …
PEDV nucleocapsid antagonizes zinc-finger antiviral protein by disrupting the interaction with its obligate co-factor, TRIM25
J Chuenchat, S Kardkarnklai, J Narkpuk… - Veterinary …, 2024 - Elsevier
The genomes of many pathogens contain high-CpG content, which is less common in most
vertebrate host genomes. Such a distinct di-nucleotide composition in a non-self invader …
vertebrate host genomes. Such a distinct di-nucleotide composition in a non-self invader …