Myeloid cells are pivotal within the immunosuppressive tumour microenvironment. The
accumulation of tumour-modified myeloid cells derived from monocytes or neutrophils …

Neutrophils are the first responders to infection and inflammation and are thus a critical
component of innate immune defense. Understanding the behavior of neutrophils as they …

The heterogeneity of the tumour immune microenvironment (TIME), organized by various
immune and stromal cells, is a major contributing factor of tumour metastasis, relapse and …

Neutrophils accumulate in solid tumors, and their abundance correlates with poor prognosis.
Neutrophils are not homogeneous, however, and could play different roles in cancer …

Cancer immunotherapies, including adoptive T cell transfer, can be ineffective because
tumors evolve to display antigen-loss-variant clones. Therapies that activate multiple …

In recent years, neutrophils have attracted increasing attention because of their cancer-
promoting effects. An elevated neutrophil-to-lymphocyte ratio is considered a prognostic …

Abstract Background Dendritic cells (DCs) are central for the initiation and regulation of
innate and adaptive immunity in the tumor microenvironment. As such, many kinds of DC …

Neutrophils are major effectors and regulators of the immune system. They play critical roles
not only in the eradication of pathogens but also in cancer initiation and progression …

Exosome is a subgroup of extracellular vesicles, which has been serving as an efficient
therapeutic tool for various diseases. Engineered exosomes are the sort of exosomes …

Objective Innate immunity plays important roles in pancreatic ductal adenocarcinoma
(PDAC), as non-T-cell-enriched tumour. Neutrophils are major players in innate immune …