The Notch signaling pathway is conserved from Drosophila to mammals and is critically
involved in developmental processes. In the immune system, it has been established that …

The Notch signaling pathway is a regulator of self-renewal and differentiation in several
tissues and cell types. Notch is a binary cell-fate determinant, and its hyperactivation has …

Transcription factor GATA-1 is required for erythropoiesis, yet its full actions are unknown.
We performed transcriptome analysis of G1E-ER4 cells, a GATA-1–null erythroblast line that …

Notch1 is known to play a critical role in regulating fates in numerous cell types, including
those of the hematopoietic lineage. Multiple defects exhibited by Notch1-deficient embryos …

The Notch pathway is a widely utilized, evolutionarily conserved regulatory system that plays
a central role in the fate decisions of multipotent precursor cells. Notch often acts by …

A major therapeutic target in the search for a cure to the devastating Alzheimer's disease is γ-
secretase. This activity resides in a multiprotein enzyme complex responsible for the …

Notch receptors are involved in a variety of cell-fate decisions that affect the development
and function of many organs, including hematopoiesis and the immune system. There are …

In the hematopoietic system, Notch signaling specifies T cell lineage fate, in part through
negative regulation of B cell and myeloid lineage development. However, we unexpectedly …

Transcription of mammalian heat shock genes can be regulated by heat shock factors (HSF)
1 and 2. Although it has been shown previously that these factors respond to distinct stimuli …

The Notch signaling pathway plays important roles in a variety of cellular processes.
Aberrant transduction of Notch signaling contributes to many diseases and cancers in …