Cancer evolution: Darwin and beyond
Clinical and laboratory studies over recent decades have established branched evolution as
a feature of cancer. However, while grounded in somatic selection, several lines of evidence …
a feature of cancer. However, while grounded in somatic selection, several lines of evidence …
Insights into molecular classifications of triple-negative breast cancer: improving patient selection for treatment
AC Garrido-Castro, NU Lin, K Polyak - Cancer discovery, 2019 - AACR
Triple-negative breast cancer (TNBC) remains the most challenging breast cancer subtype
to treat. To date, therapies directed to specific molecular targets have rarely achieved …
to treat. To date, therapies directed to specific molecular targets have rarely achieved …
Multiomics in primary and metastatic breast tumors from the AURORA US network finds microenvironment and epigenetic drivers of metastasis
Abstract The AURORA US Metastasis Project was established with the goal to identify
molecular features associated with metastasis. We assayed 55 females with metastatic …
molecular features associated with metastasis. We assayed 55 females with metastatic …
A single‐cell RNA expression atlas of normal, preneoplastic and tumorigenic states in the human breast
To examine global changes in breast heterogeneity across different states, we determined
the single‐cell transcriptomes of> 340,000 cells encompassing normal breast, preneoplastic …
the single‐cell transcriptomes of> 340,000 cells encompassing normal breast, preneoplastic …
Clinical implications of intratumor heterogeneity: challenges and opportunities
S Ramón y Cajal, M Sesé, C Capdevila… - Journal of Molecular …, 2020 - Springer
In this review, we highlight the role of intratumoral heterogeneity, focusing on the clinical and
biological ramifications this phenomenon poses. Intratumoral heterogeneity arises through …
biological ramifications this phenomenon poses. Intratumoral heterogeneity arises through …
Immunosuppressive reprogramming of neutrophils by lung mesenchymal cells promotes breast cancer metastasis
Neutrophils, the most abundant innate immune cells, function as crucial regulators of the
adaptive immune system in diverse pathological conditions, including metastatic cancer …
adaptive immune system in diverse pathological conditions, including metastatic cancer …
[HTML][HTML] Lipid-laden lung mesenchymal cells foster breast cancer metastasis via metabolic reprogramming of tumor cells and natural killer cells
While the distant organ environment is known to support metastasis of primary tumors, its
metabolic roles in this process remain underdetermined. Here, in breast cancer models, we …
metabolic roles in this process remain underdetermined. Here, in breast cancer models, we …
Multi-cancer analysis of clonality and the timing of systemic spread in paired primary tumors and metastases
Metastasis is the primary cause of cancer-related deaths, but the natural history, clonal
evolution and impact of treatment are poorly understood. We analyzed whole-exome …
evolution and impact of treatment are poorly understood. We analyzed whole-exome …
The bone microenvironment invigorates metastatic seeds for further dissemination
Metastasis has been considered as the terminal step of tumor progression. However, recent
genomic studies suggest that many metastases are initiated by further spread of other …
genomic studies suggest that many metastases are initiated by further spread of other …
The landscape of targeted therapies in TNBC
E Vagia, D Mahalingam, M Cristofanilli - Cancers, 2020 - mdpi.com
Triple negative breast cancer (TNBC) constitutes the most aggressive molecular subtype
among breast tumors. Despite progress on the underlying tumor biology, clinical outcomes …
among breast tumors. Despite progress on the underlying tumor biology, clinical outcomes …