Since the original identification of the T helper 17 (Th17) subset in 2005, it has become
evident that these cells do not only contribute to host defence against pathogens, such as …

Sarcoidosis is a systemic inflammatory disorder of unknown etiology characterized by tissue
infiltration with macrophages and lymphocytes and associated non-caseating granuloma …

We provide a comprehensive update on the cellular components and their functional
implications in sarcoid granuloma formation, with special emphasis on the specific …

Thoracic sarcoidosis is the most common form of sarcoidosis, encompassing a
heterogeneous group of patients with a wide range of clinical features and associated …

Regulatory T cells (Tregs) suppress the activation and subsequent effector functions of CD4
effector T cells (Teffs). However, molecular mechanisms that enforce Treg-mediated …

Sarcoidosis is a granulomatous multiorgan disease, thought to result from exposure to yet
unidentified antigens in genetically susceptible individuals. The exaggerated inflammatory …

Succinate is an important metabolite that modulates metabolism of immune cells and cancer
cells in the tumor microenvironment (TME). Herein, we report that polyethylene succinate …

Sarcoidosis is an immune-mediated disorder. Its immunopathology has been steadily
mapped out over the past few decades. Despite this, the underpinning mechanisms for …

Publisher Correction: Sarcoidosis Johan Grunewald, Jan C. Grutters, Elizabeth
V. Arkema, Lesley Ann Saketkoo, David R. Moller and Joachim M ller …

Rationale Disease course in sarcoidosis is highly variable. Bronchoalveolar lavage fluid and
mediastinal lymph nodes show accumulation of activated T cells with a T-helper (Th) 17.1 …