Age-associated neurological diseases represent a profound challenge in biomedical
research as we are still struggling to understand the interface between the aging process …

The scarcity of live human brain cells for experimental access has for a long time limited our
ability to study complex human neurological disorders and elucidate basic neuroscientific …

Technologies for engineering synthetic transcription factors have enabled many advances in
medical and scientific research. In contrast to existing methods based on engineering of …

The interest in cultured meat is increasing because of the problems with conventional
livestock industry. Recently, many studies related to cultured meat have been conducted, but …

The abilities of stem cells to self-renew and form different mature cells expand the
possibilities of applications in cell-based therapies such as tissue recomposition in …

Overexpression of exogenous fate-specifying transcription factors can directly reprogram
differentiated somatic cells to target cell types. Here, we show that similar reprogramming …

Transdifferentiation (TD) is a recent advancement in somatic cell reprogramming. The direct
conversion of TD eliminates the pluripotent intermediate state to create cells that are ideal …

Abstract Disclosed herein are Clustered Regularly Interspaced Short Palindromic Repeats
(CRISPR)/CRISPR-associated (Cas) 9-based system related compositions and methods of …

DOI: 10.1002/adma. 201601900 minimal safety issues, in clinical settings.[8d] A study
reported nonviral polymer nanoparticle-mediated direct conversion of mouse fibroblasts to …

Cellular reprogramming holds tremendous potential for cell therapy and regenerative
medicine. Recently, fibroblasts have been directly converted into induced neurons (iNs) by …