Radioactive main group and rare earth metals for imaging and therapy

TI Kostelnik, C Orvig - Chemical reviews, 2018 - ACS Publications
Radiometals possess an exceptional breadth of decay properties and have been applied to
medicine with great success for several decades. The majority of current clinical use …

New developments in the production of theranostic pairs of radionuclides

SM Qaim, B Scholten, B Neumaier - Journal of Radioanalytical and …, 2018 - Springer
A brief historical background of the development of the theranostic approach in nuclear
medicine is given and seven theranostic pairs of radionuclides, namely 44g Sc/47 Sc, 64 …

State of the art in radiolabeling of antibodies with common and uncommon radiometals for preclinical and clinical immuno-PET

M Chomet, GAMS van Dongen… - Bioconjugate chemistry, 2021 - ACS Publications
Inert and stable radiolabeling of monoclonal antibodies (mAb), antibody fragments, or
antibody mimetics with radiometals is a prerequisite for immuno-PET. While radiolabeling is …

[HTML][HTML] Cross section measurement of terbium radioisotopes for an optimized 155Tb production with an 18 MeV medical PET cyclotron

G Dellepiane, P Casolaro, C Favaretto… - Applied radiation and …, 2022 - Elsevier
Abstract 155 Tb [t 1/2= 5.32 d, E γ= 87 keV (32%); 105 keV (25%)(IAEA, 2021) is a novel
promising radionuclide for theranostic applications in nuclear medicine. Its physical …

De novo approaches to the solid-phase separation of Titanium (IV) and Scandium (III): translating speciation data to selective on-bead chelation toward applications in …

AJ Koller, L Wang, M Deluca, O Glaser… - Inorganic …, 2023 - ACS Publications
The solution chemistry of the hydrolytic, early-transition-metal ions Ti4+ and Sc3+ represents
a coordination chemistry challenge with important real-world implications, specifically in the …

[HTML][HTML] 47Sc and 46Sc cross-section measurement for an optimized 47Sc production with an 18 MeV medical PET cyclotron

G Dellepiane, P Casolaro, I Mateu, P Scampoli… - Applied Radiation and …, 2022 - Elsevier
The availability of novel radionuclides plays a fundamental role in the development of
personalized nuclear medicine. In particular, there is growing interest in pairs formed by two …

Cutting edge rare earth radiometals: prospects for cancer theranostics

AWE Sadler, L Hogan, B Fraser… - EJNMMI Radiopharmacy …, 2022 - Springer
Background With recent advances in novel approaches to cancer therapy and imaging, the
application of theranostic techniques in personalised medicine has emerged as a very …

Cyclotron production and separation of scandium radionuclides from natural titanium metal and titanium dioxide targets

CS Loveless, JR Blanco, GL Diehl… - Journal of Nuclear …, 2021 - Soc Nuclear Med
Theranostic strategies involve select radionuclides that allow diagnostic imaging and
tailored radionuclide therapy in the same patient. An example of a Food and Drug …

Cyclotron production of 43Sc and 44gSc from enriched 42CaO, 43CaO, and 44CaO targets

KV Becker, E Aluicio-Sarduy, T Bradshaw… - Frontiers in …, 2023 - frontiersin.org
Introduction: 43Sc and 44gSc are both positron-emitting radioisotopes of scandium with
suitable half-lives and favorable positron energies for clinical positron emission tomography …

Developments toward the Implementation of 44Sc Production at a Medical Cyclotron

NP van der Meulen, R Hasler, Z Talip, PV Grundler… - Molecules, 2020 - mdpi.com
44Sc has favorable properties for cancer diagnosis using Positron Emission Tomography
(PET) making it a promising candidate for application in nuclear medicine. The …