Endoplasmic reticulum stress and homeostasis in reproductive physiology and pathology

E Guzel, S Arlier, O Guzeloglu-Kayisli… - International journal of …, 2017 - mdpi.com
The endoplasmic reticulum (ER), comprises 60% of the total cell membrane and interacts
directly or indirectly with several cell organelles ie, Golgi bodies, mitochondria and …

Heat shock proteins and their role in pregnancy: Redefining the function of “Old Rum in a New Bottle”

B Jee, R Dhar, S Singh, S Karmakar - Frontiers in Cell and …, 2021 - frontiersin.org
Pregnancy in humans is a multi-step complex physiological process comprising three
discrete events, decidualization, implantation and placentation. Its overall success depends …

Effect of resveratrol and metformin on ovarian reserve and ultrastructure in PCOS: an experimental study

S Furat Rencber, S Kurnaz Ozbek, C Eraldemır… - Journal of ovarian …, 2018 - Springer
Background PCOS is a reproductive hormonal abnormality and a metabolic disorder. It is
frequently associated with insulin resistance, hyperandrogenism, chronic inflammation, and …

Endoplasmic reticulum (ER) stress and hypoxia response pathways interact to potentiate hypoxia-inducible factor 1 (HIF-1) transcriptional activity on targets like …

ER Pereira, K Frudd, W Awad… - Journal of Biological …, 2014 - ASBMB
Cells respond to suboptimal microenvironments by activating stress signaling pathways, like
the unfolded protein response and hypoxia-induced transcription factors HIF-1/2, to restore …

Glucose-regulated protein 78 controls cross-talk between apoptosis and autophagy to determine antiestrogen responsiveness

KL Cook, AN Shajahan, A Wärri, L Jin… - Cancer research, 2012 - AACR
While more than 70% of breast cancers express estrogen receptor-α (ER+), endocrine
therapies targeting these receptors often fail. The molecular mechanisms that underlie …

Evaluating endoplasmic reticulum stress and unfolded protein response through the lens of ecology and evolution

KN Yap, KL Yamada, S Zikeli, H Kiaris… - Biological …, 2021 - Wiley Online Library
Considerable progress has been made in understanding the physiological basis for
variation in the life‐history patterns of animals, particularly with regard to the roles of …

Systematic in‐depth proteomic analysis of mitochondria‐associated endoplasmic reticulum membranes in mouse and human testes

X Wang, Y Wen, J Dong, C Cao, S Yuan - Proteomics, 2018 - Wiley Online Library
Mitochondria‐associated endoplasmic reticulum membranes (MAMs) regulate important
cellular functions including calcium signaling, bioenergetics, and apoptosis during …

[HTML][HTML] Regulatory T cells, inflammation, and endoplasmic reticulum stress in women with defective endometrial receptivity

M Galgani, L Insabato, G Calì, AN Della Gatta, P Mirra… - Fertility and sterility, 2015 - Elsevier
Objective To investigate immunologic parameters and endoplasmic reticulum (ER) stress
associated with unexplained infertility. Design Case-control study. Setting Academic center …

The role of endoplasmic reticulum stress in endometriosis

HRAK Al-Hetty, AD Jabbar, VF Eremin… - Cell Stress and …, 2023 - Springer
Endometriosis is a chronic gynecologic disorder characterized by abnormal growth of
endometrium-like tissues in the ectopic regions of the pelvic peritoneum. The …

The endoplasmic reticulum stress marker, glucose-regulated protein-78 (GRP78) in visceral adipocytes predicts endometrial cancer progression and patient survival

K Matsuo, MJ Gray, DY Yang, SA Srivastava… - Gynecologic …, 2013 - Elsevier
OBJECTIVE: Currently, accurately identifying endometrial cancer patients at high risk for
recurrence remains poor. To ascertain if changes in the endoplasmic reticulum (ER) stress …