With both catalytic and genetic functions, ribonucleic acid (RNA) is perhaps the most
pluripotent chemical species in molecular biology, and its functions are intimately linked to …

Although aminoglycosides have been used as antibacterials for decades, their use has
been hindered by their inherent toxicity and the resistance that has emerged to these …

Silver nanoparticles (AgNPs) are extensively used for their antibacterial properties in a
diverse set of applications, ranging from the treatment of municipal wastewater to infection …

Aminoglycoside ototoxicity has been related to a surprisingly large number of cellular
structures and metabolic pathways. The finding that patients with mutations in mitochondrial …

Nonsense mutations promote premature translational termination and represent the
underlying cause of a large number of human genetic diseases. The aminoglycoside …

As an FDA-approved drug, glycylcycline tigecycline has been used to treat complicated
microbial infections. However, recent studies in multiple hematologic and malignant solid …

New pseudo-di-and pseudo-trisaccharide derivatives of the aminoglycoside drug G418
were designed, synthesized and their ability to readthrough nonsense mutations was …

This minireview explores mitochondria as a site for antibiotic-host interactions that lead to
pathophysiologic responses manifested as nonantibacterial side effects. Mitochondrion …

Sensorineural hearing loss often results from damaged or deficient inner ear hair cells.
Mitochondrial 12S rRNA 1555A> G mutation has been associated with hearing loss in many …

Mutations of mitochondrial DNA are linked to many human diseases. Despite the
identification of a large number of variants in the mitochondrially encoded rRNA (mt-rRNA) …