Chondroprotective drugs in degenerative joint diseases

G Verbruggen - Rheumatology, 2006 - academic.oup.com
Catabolic cytokine and anabolic growth factor pathways control destruction and repair in
osteoarthritis (OA). A unidirectional TNF-α/IL-1-driven cytokine cascade disturbs the …

[HTML][HTML] The effects of oral glucosamine on joint health: is a change in research approach needed?

JA Block, TR Oegema, JD Sandy, A Plaas - Osteoarthritis and Cartilage, 2010 - Elsevier
OBJECTIVE: Oral glucosamine (GlcN) has been widely studied for its potential therapeutic
benefits in alleviating the pain and disability of osteoarthritis (OA). Its popularity has grown …

[HTML][HTML] Glucosamine and chondroitin sulfate regulate gene expression and synthesis of nitric oxide and prostaglandin E2 in articular cartilage explants

PS Chan, JP Caron, GJM Rosa, MW Orth - Osteoarthritis and cartilage, 2005 - Elsevier
OBJECTIVE: Glucosamine (GLN) and chondroitin sulfate (CS) are widely used to alleviate
symptoms of osteoarthritis (OA). However, the mechanism (s) of action of these …

[HTML][HTML] Glucosamine decreases expression of anabolic and catabolic genes in human osteoarthritic cartilage explants

EJ Uitterlinden, H Jahr, JLM Koevoet… - Osteoarthritis and …, 2006 - Elsevier
OBJECTIVE: To investigate the effect of glucosamine (GlcN) in a human osteoarthritic
explant model on expression of genes involved in anabolic and catabolic activities of …

[图书][B] Amino acids and proteins for the athlete: The anabolic edge

MG Di Pasquale - 2007 - taylorfrancis.com
Extensively updated with all chapters rewritten and double the information and references,
Amino Acids and Proteins for the Athlete: The Anabolic Edge, Second Edition reflects the …

Short-term gene expression changes in cartilage explants stimulated with interleukin beta plus glucosamine and chondroitin sulfate.

PS Chan, JP Caron, MW Orth - The Journal of rheumatology, 2006 - jrheum.org
OBJECTIVE: To determine the short-term effects of glucosamine (GLN) and chondroitin
sulfate (CS) on expression of genes encoding inflammatory mediators and matrix enzymes …

Effect of glucosamine and chondroitin sulfate on regulation of gene expression of proteolytic enzymes and their inhibitors in interleukin-1–challenged bovine articular …

PS Chan, JP Caron, MW Orth - American journal of veterinary …, 2005 - Am Vet Med Assoc
Objective—To determine the effects of glucosamine (GLN) and chondroitin sulfate (CS), at
concentrations attainable in vivo, on expression of genes encoding proteolytic enzymes …

Effects of chondroitin and glucosamine sulfate in a dietary bar formulation on inflammation, interleukin-1β, matrix metalloprotease-9, and cartilage damage in arthritis

MM Chou, N Vergnolle, JJ McDougall… - Experimental …, 2005 - journals.sagepub.com
This study examined the effects of chondroitin sulfate (CS) alone and CS plus glucosamine
sulfate (GS) in a dietary bar formulation on inflammatory parameters of adjuvant-induced …

[PDF][PDF] The role of glucosamine and chondroitin sulfate in treatment for and prevention of osteoarthritis in animals

KM Neil, JP Caron, MW Orth - Journal of the American Veterinary …, 2005 - researchgate.net
Joint disease, in particular osteoarthritis, is an impor-tant cause of lameness and debilitation
for humans and other animals. Presently, a number of pharmacologic agents are available …

Therapeutic efficacy of undenatured type‐II collagen (UC‐II) in comparison to glucosamine and chondroitin in arthritic horses1

RC Gupta, TD Canerdy, P Skaggs… - Journal of veterinary …, 2009 - Wiley Online Library
The present investigation evaluated arthritic pain in horses receiving daily placebo,
undenatured type II collagen (UC‐II) at 320, 480, or 640 mg (providing 80, 120, and 160 mg …