Pathogenesis of autoimmune disease

DS Pisetsky - Nature Reviews Nephrology, 2023 - nature.com
Autoimmune diseases are a diverse group of conditions characterized by aberrant B cell
and T cell reactivity to normal constituents of the host. These diseases occur widely and …

Unexplained post-acute infection syndromes

J Choutka, V Jansari, M Hornig, A Iwasaki - Nature medicine, 2022 - nature.com
SARS-CoV-2 is not unique in its ability to cause post-acute sequelae; certain acute
infections have long been associated with an unexplained chronic disability in a minority of …

Gut barrier disruption and chronic disease

J Martel, SH Chang, YF Ko, TL Hwang… - Trends in Endocrinology …, 2022 - cell.com
The intestinal barrier protects the host against gut microbes, food antigens, and toxins
present in the gastrointestinal tract. However, gut barrier integrity can be affected by intrinsic …

Unravelling the collateral damage of antibiotics on gut bacteria

L Maier, CV Goemans, J Wirbel, M Kuhn, C Eberl… - Nature, 2021 - nature.com
Antibiotics are used to fight pathogens but also target commensal bacteria, disturbing the
composition of gut microbiota and causing dysbiosis and disease. Despite this well-known …

Enterococcus peptidoglycan remodeling promotes checkpoint inhibitor cancer immunotherapy

ME Griffin, J Espinosa, JL Becker, JD Luo, TS Carroll… - Science, 2021 - science.org
The antitumor efficacy of cancer immunotherapy can correlate with the presence of certain
bacterial species within the gut microbiome. However, many of the molecular mechanisms …

The immunology of systemic lupus erythematosus

GC Tsokos - Nature Immunology, 2024 - nature.com
Understanding the pathogenesis and clinical manifestations of systemic lupus
erythematosus (SLE) has been a great challenge. Reductionist approaches to understand …

The Many Faces of Enterococcus spp.—Commensal, Probiotic and Opportunistic Pathogen

B Krawczyk, P Wityk, M Gałęcka, M Michalik - Microorganisms, 2021 - mdpi.com
Enterococcus spp. are Gram-positive, facultative, anaerobic cocci, which are found in the
intestinal flora and, less frequently, in the vagina or mouth. Enterococcus faecalis and …

[HTML][HTML] Role of microbiota-derived short-chain fatty acids in nervous system disorders

R Mirzaei, B Bouzari, SR Hosseini-Fard… - Biomedicine & …, 2021 - Elsevier
During the past decade, accumulating evidence from the research highlights the suggested
effects of bacterial communities of the human gut microbiota and their metabolites on health …

Pathogenesis of systemic lupus erythematosus: risks, mechanisms and therapeutic targets

MK Crow - Annals of the rheumatic diseases, 2023 - ard.bmj.com
Research elucidating the pathogenesis of systemic lupus erythematosus (SLE) has defined
two critical families of mediators, type I interferon (IFN-I) and autoantibodies targeting nucleic …

Gut microbiome, liver immunology, and liver diseases

R Wang, R Tang, B Li, X Ma, B Schnabl… - Cellular & molecular …, 2021 - nature.com
The gut microbiota is a complex and plastic consortium of microorganisms that are intricately
connected with human physiology. The liver is a central immunological organ that is …