Tau protein is involved in various cellular processes, including having a canonical role in
binding and stabilization of microtubules in neurons. Tauopathies are neurodegenerative …

The ubiquitin–proteasome system (UPS) and the autophagy-lysosome system are two major
protein quality control mechanisms in eukaryotic cells. While the UPS has been considered …

Although women experience significantly higher tau burden and increased risk for
Alzheimer's disease (AD) than men, the underlying mechanism for this vulnerability has not …

Protein misfolding and aggregation is a common hallmark in neurodegenerative disorders,
including Alzheimer's disease (AD), Parkinson's disease (PD), and fronto-temporal dementia …

Ubiquitin signaling is a sequence of events driving the fate of a protein based on the type of
ubiquitin modifications attached. In the case of neurodegenerative diseases, ubiquitin …

Long-term memory (LTM) formation requires transient changes in the activity of intracellular
signaling cascades that are thought to regulate new gene transcription and de novo protein …

Most proteins undergo posttranslational modification such as acetylation, methylation,
phosphorylation, biotinylation, and ubiquitination to regulate various cellular processes …

Abstract Ubiquitin‐specific protease 14 (USP14) is a ubiquitin‐specific protease that is
associated with the proteasome and plays important roles in cellular functions, viral …

The Ubiquitin-Proteasome Pathway (UPP), which is critical for normal function in the
nervous system and is implicated in various neurological diseases, requires the small …

Intervertebral disc degeneration (IVDD) is a general disorder that results in low back pain
and disability among many affected individuals. However, the current treatments for IVDD …