The main role of acidity and pH is to confer microbial stability to wines. No less relevant, they
also preserve the color and sensory properties of wines. Tartaric and malic acids are …

In our modern 'omics era, metabolic flux analysis (fluxomics) represents the physiological
counterpart of its siblings transcriptomics, proteomics and metabolomics. Fluxomics …

Accurate determination of intracellular metabolite levels requires well-validated procedures
for sampling and sample treatment. Several methods exist for metabolite extraction, but the …

The heterologous expression of a highly functional xylose isomerase pathway in
Saccharomyces cerevisiae would have significant advantages for ethanol yield, since the …

Metabolic microenvironment of tumor cells is influenced by oncogenic signaling and tissue-
specific metabolic demands, blood supply, and enzyme expression. To elucidate tumor …

Fermenting glucose in the presence of enough oxygen to support respiration, known as
aerobic glycolysis, is believed to maximize growth rate. We observed increasing aerobic …

High cell density cultivation of Pichia pastoris has to cope with several technical limitations,
most importantly the transfer of oxygen. By applying hypoxic conditions to chemostat …

The yeast Saccharomyces cerevisiae can show different metabolic phenotypes (eg
fermentation and respiration). Based on data from the literature, we argue that the substrate …

Abstract Background The yeast Saccharomyces cerevisiae is able to adjust to external
oxygen availability by utilizing both respirative and fermentative metabolic modes. Adjusting …

Regardless of bacteria or eukaryotic microorganism hosts, improving their ability to express
heterologous proteins is always a goal worthy of elaborate study. In addition to traditional …