Hypoxia development in tumor is closely associated with its increased aggressiveness and
strong resistance to therapy, leading to the poor prognosis in several cancer types …

There have been many attempts to provide sufficient nutrients, especially oxygen, to
engineered large tissues to overcome the effects of hypoxia or poor vascularization …

Diabetic wounds are among the major healthcare challenges, consuming billions of dollars
of resources and resulting in high numbers of morbidity and mortality every year. Lack of …

Cell survival during the early stages of transplantation and before new blood vessels
formation is a major challenge in translational applications of 3D bioprinted tissues …

Abstract Engineering three-dimensional (3D) tissues in clinically relevant sizes have
demonstrated to be an effective solution to bridge the gap between organ demand and the …

Tissue engineering (TE) has provided promising strategies for regenerating tissue defects,
but few TE approaches have been translated for clinical applications. One major barrier in …

Oxygen is critical to the survival, function and fate of mammalian cells. Oxygen tension
controls cellular behavior through metabolic programming, which in turn controls tissue …

Oxygen (O2) generating biomaterials are emerging as important compositions to improve
our capabilities in supporting tissue engineering and regenerative therapeutics. Several in …

Manufacturing macroscale cell-laden architectures is one of the biggest challenges faced
nowadays in the domain of tissue engineering. Such living constructs, in fact, pose strict …

3D bioprinting directly into injured sites in a surgical setting, intraoperative bioprinting (IOB),
is an effective process, in which the defect information can be rapidly acquired and then …