Immune cell development and activation demand the precise and coordinated control of
transcriptional programmes. Three-dimensional (3D) organization of the genome has …

For many infections and almost all vaccines, neutralizing-antibody-mediated immunity is the
primary basis and best functional correlate of immunological protection. Durable long-term …

Antibodies are an essential element of the immune response to infection, and in long‐term
protection upon re‐exposure to the same micro‐organism. Antibodies are produced by …

Chromatin misfolding has been implicated in cancer pathogenesis; yet, its role in therapy
resistance remains unclear. Here, we systematically integrated sequencing and imaging …

Higher-order spatial organization of the genome into chromatin compartments (permissive
and repressive), self-associating domains (TADs), and regulatory loops provides structural …

During cellular differentiation chromosome conformation is intricately remodelled to support
the lineage-specific transcriptional programs required for initiating and maintaining lineage …

In response to infection or immunization, antibodies are produced that provide protection
against re-exposure with the same pathogen. These antibodies can persist at high titers for …

The contribution of three-dimensional genome organization to physiological ageing is not
well known. Here we show that large-scale chromatin reorganization distinguishes young …

Abstract BACH2 [BTB (broad-complex, tramtrak and bric à brac) and CNC (cap 'n'collar)
homolog 2] is known as a transcriptional repressor and broadly functions in regulating …

Humoral immunity provides protection from pathogenic infection and is mediated by
antibodies following the differentiation of naive B cells (nBs) to antibody‐secreting cells …