Molecular hybridization is one of the recent stratagems in medicinal chemistry to synthesize
a novel hybrid molecule having better affinity and efficacy by combining two or more …

Pathogenic bacteria, with their innate resistance to drugs, pose a constant threat to human
health and well-being and put a persistent strain on the health care system. Development of …

In a previous study, the 1-(4-fluorobenzyl)-5-bromolindolin-2, 3‑dione (FBID) molecule was
synthesized by adding isatin and K 2 CO 3 to acetonitrile, followed by the addition of 4 …

In this work, a novel series of hydrazineylideneindolinone linked to phenoxymethyl-1, 2, 3-
triazole derivatives were designed, synthesized, and evaluated for their anti-α-glucosidase …

Herein, the one-step, multi-component reaction (MCR) of a series of spirooxindole-
pyranopyrazole derivatives (5a-g), via a Knoevenagel condensation and Michael addition …

Leishmaniasis being one of the six major tropical diseases that affects nearly 0.7–1.3 million
people annually, has so far limited and high toxic therapeutic options. Herein, we report the …

Exploring novel classes of antimicrobial therapeutics is an excellent approach to face the
different health problems such as microbial resistance. In this context, hybrid molecules of …

In the present study, a combination of theoretical and experimental methods has been
employed to evaluate and understand the molecular geometrical properties of 1-(4 …

Abstract Isatis indigotica Fort.(Chinese woad) is a species with an ancient and well-
documented history as an indigo dye and medicinal plant. It is often confused with Isatis …

Keeping in view the varying therapeutic attributes of 5‐nitrofuran and isatin derivatives,
novel 5‐nitrofuran‒isatin molecular hybrids (2, 5–7) were synthesized by standard …